NuRD

The NURD complex, in molecular biology, is a complex with both ATP-dependent chromatin-remodelling and histone-deacetylase activities.^[1]

The nucleosome remodelling and histone deacetylase NuRD complex contains seven subunits: the histone deacetylase core proteins HDAC1 and HDAC2, the histone-binding proteins RbAp46 and RbAp48, the metastasis-associated proteins MTA1 and MTA2, the methyl-CpG-binding domain protein MBD3 and the chromodomain-helicase-DNA-binding protein Mi2 or CHD2.

The histone deacetylases HDAC1 and HDAC2 and the histone binding proteins RbAp48 and RbAp46 form a core complex shared between NuRD and Sin3-histone deacetylase complexes. ^[2] See also ^[3]

References

1. ^ Xue Y, Wong J, Moreno GT, Young MK, Côté J, Wang W (1998). "NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities.". Mol Cell 2 (6): 851–61. doi:10.1016/S1097-2765(00)80299-3. PMID 9885572. http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9885572. 
2. ^ Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.". Genes Dev 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. PMC 316920. PMID 10444591. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316920. 
3. ^ Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D. (1998). "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.". Cell 95 (5): 279–89.