Neurohypophysial hormone

Neurohypophysial hormones, N-terminal Domain
crystal structure analysis of deamino-oxytocin. conformational flexibility and receptor binding
Identifiers
Symbol	Hormone_4
Pfam	PF00220
InterPro	IPR022423
PROSITE	PDOC00237
SCOP	1xy1
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

Neurohypophysial hormones, C-terminal Domain
solution structure of the monomeric form of a mutant unliganded bovine neurophysin, minimized average structure
Identifiers
Symbol	Hormone_5
Pfam	PF00184
InterPro	IPR000981
PROSITE	PDOC00237
SCOP	1xy2
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

Neurohypophysial hormones is a family of structurally and functionally related peptide hormones that includes oxytocin and vasopressin.

Hypophysis refers to the pituitary gland.

Oxytocin mediates contraction of the smooth muscle of the uterus and mammary gland, while vasopressin has antidiuretic action on the kidney, and mediates vasoconstriction of the peripheral vessels.^[1] In common with most active peptides, both hormones are synthesised as larger protein precursors that are enzymatically converted to their mature forms.

Members of this family are found in birds, fish, reptiles and amphibians (mesotocin, isotocin, valitocin, glumitocin, aspargtocin, vasotocin, seritocin, asvatocin, phasvatocin), in worms (annetocin), octopi (cephalotocin), Locusta migratoria (Migratory locust) (locupressin or neuropeptide F1/F2) and in molluscs (conopressins G and S).^[2]

References

1. ^ Acher R, Chauvet J (1988). "Structure, processing and evolution of the neurohypophysial hormone-neurophysin precursors". Biochimie 70 (9): 1197–1207. doi:10.1016/0300-9084(88)90185-X. PMID 3147712. 
2. ^ Michel G, Acher R, Chauvet J, Ouedraogo Y, Chou J, Chait BT (1995). "A new neurohypophysial peptide, seritocin ([Ser5,Ile8]-oxytocin), identified in a dryness-resistant African toad, Bufo regularis". Int. J. Pept. Protein Res. 45 (5): 482–487. PMID 7591488. 

This article includes text from the public domain Pfam and InterPro IPR000981