NWD1

NWD1: NACHT and WD repeat domain containing 1

Identifiers

Symbols NWD1; MGC134940

External IDs MGI: 2442268 HomoloGene: 72261 GeneCards: NWD1 Gene

Gene Ontology

Molecular function • nucleotide binding
• ATP binding

Biological process • transcription initiation
• regulation of transcription, DNA-dependent

Sources: Amigo / QuickGO

Orthologs

Species Human Mouse

Entrez 284434 319555

Ensembl ENSG00000188039 ENSMUSG00000048148

UniProt Q149M9 A6H603

RefSeq (mRNA) NM_001007525 NM_176940.5

RefSeq (protein) NP_001007526 NP_795914.3

Location (UCSC) Chr 19:
16.83 – 16.93 Mb Chr 8:
75.17 – 75.24 Mb

PubMed search [1] [2]

NWD1, short for NACHT and WD repeat domain containing 1, is a gene found in vertebrates, which encodes a protein that contains a NACHT domain and a WD40 repeat domain. It was originally identified during a search for immune system genes in zebrafish as a protein coding sequence related to APAF1; orthologs were subsequently identified in mammalian species.^[1] The NWD1 gene of humans is located on chromosome 19. The function of the NWD1 protein is currently unknown.

References

^ Stein C, Caccamo M, Laird G, Leptin M (2007). "Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish". Genome Biol. 8 (11): R251. doi:10.1186/gb-2007-8-11-r251. PMC 2258186. PMID 18039395. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2258186.

Further reading

Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.

Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

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