Myogenic determination factor 5

Myogenic determination factor 5
Myf5 domain
Identifiers
Symbol Myf5
Pfam PF12232
InterPro IPR022032
Basic domain
PDB 1mdy EBI.jpg
crystal structure of myod bhlh domain bound to dna: perspectives on dna recognition and implications for transcriptional activation
Identifiers
Symbol Basic
Pfam PF01586
InterPro IPR002546
PROSITE PDOC00038
SCOP 1mdy

In molecular biology, the myogenic determination factor 5 proteins are a family of proteins found in eukaryotes. This family includes the Myf5 protein, which is responsible for directing cells to the skeletal myocyte lineage during development. Myf5 is likely to act in a similar way to the other MRF4 proteins such as MyoD which perform the same function. These are histone acetyltransferases and histone deacetylases which activate and repress genes involved in the myocyte lineage.

Myogenic determination factor 5 proteins contain three conserved protein domains. A C-terminal Myf5 domain, a central basic helix-loop-helix (bHLH) domain and an N-terminal basic domain. The bHLH region mediates specific DNA binding.[1] With 12 residues of the basic domain involved in DNA binding.[2] The basic domain forms an extended alpha helix in the structure.

References

This article includes text from the public domain Pfam and InterPro IPR022032

This article includes text from the public domain Pfam and InterPro IPR002546


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