Michael E. Jung

Oxetanocin A

Halomon

MDV3100

Michael E. Jung is Professor of Chemistry in the Department of Chemistry and Biochemistry at the University of California at Los Angeles.

Michael Jung was born May 14, 1947 in New Orleans, Louisiana.^[1] He received a B.A. from Rice University in Houston, Texas in 1969 and a Ph.D. from Columbia University in New York City in 1973 where he did research with Gilbert Stork. He then obtained a NATO Postdoctoral Fellowship to work with Albert Eschenmoser at the Eidgenössische Technische Hochschule in Zürich, Switzerland. In 1974, he joined the faculty at UCLA, where he has spent his career.

Michael Jung's research is focused on the development of new reactions for organic synthesis, including the Jung "non-aldol aldol" protocol, an alternate method for obtaining aldol products without using the classical aldol reaction.^[2] He has also developed chemical syntheses for a variety of natural products with antitumor and antiviral properties including tedanolides,^[3][4][5] oxetanocin,^[6] halomons,^[7] and xestobergsterol.^[8] Other research interests include the bridged Robinson annulation and the mixed Lewis acid Diels-Alder process.^[9]

Jung's research group developed an antagonist of the androgen receptor, MDV3100, which is in phase 1/2 clinical trials for the treatment of hormone refractory prostate cancer.^[10][11]

Awards won by Michael Jung include the American Chemical Society's Arthur C. Cope Scholar Award,^[12] the Glenn T. Seaborg Award, and the Gold Shield Faculty Prize.^[13]

References

1. ^ UCLA, Department of Chemistry and Biochemistry
2. ^ Research Interests, Organic Chemistry Faculty, UCLA
3. ^ M. E. Jung and D. Yoo, "Synthesis of the C1 -C12 Fragment of the Tedanolides. Selective Hydroboration-protonation of Allylic Alcohol Approach," Tetrahedron Lett. 2008, 49, 816-819.
4. ^ M. E. Jung and C. P. Lee, "Synthesis of a Fully Functionalized Protected C1-C11 Fragment for the Synthesis of the Tedanolides," Org. Lett. 2001, 3, 333-336.
5. ^ M. E. Jung and C. P. Lee, "Use of the Non-Aldol Aldol Process in the Synthesis of the C1-C11 Fragment of the Tedanolides: Use of Lactol Ethers in Place of Tetrahydrofurans," Tetrahedron Lett. 2000, 41, 9719-9723.
6. ^ Michael E. Jung and Christopher J. Nichols, "Highly Stereoselective Synthesis of trans, trans-4-Aryl-2,3-oxetanedimerthanols: Preparation of Oxetanocin A Analogues," Tetrahedron Lett. 1996, 37, 7667-7670.
7. ^ Michael E. Jung and Michael H. Parker, "Synthesis of Several Naturally Occurring Polyhalogenated Monoterpenes of the Halomon Class," J. Org. Chem. 1997, 62, 7094-7095.
8. ^ M. E. Jung and T. W. Johnson, "First Total Synthesis of Xestobergsterol A and Active Structural Analogues of the Xestobergsterols," Tetrahedron 2001, 57, 1449-1481.
9. ^ Current Research Interest, UCLA
10. ^ "New Prostate Cancer Agent Class: Rational design leads to novel drug candidate, now in clinical trials", Chemical and Engineering News, September 22, 2008, Volume 86, Number 38 pp. 84-87
11. ^ UCLA Chemistry and Biochemistry
12. ^ Recipients of the Arthur C. Cope Scholar Award, American Chemical Society
13. ^ Prized Faculty, UCLA Today

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