Methiodide

In organic chemistry, a methiodide is a chemical derivative produced by the reaction of a compound with methyl iodide. Methiodides may be formed through the methylation of amines:

R₃N + CH₃I → (CH₃)R₃N⁺I⁻

Methiodides are generally prepared to alter chemical or pharmacological properties. Examples include:

• Cocaine methiodide, a charged cocaine analog which cannot pass the blood brain barrier and enter the brain^[1]
• Bicuculline methiodide, a water-soluble form of bicuculline

References

1. ^ Hill ER, Tian J, Tilley MR, Zhu MX, Gu HH (2009). "Potencies of Cocaine Methiodide on Major Cocaine Targets in Mice". PLoS ONE 4 (10): e7578. doi:10.1371/journal.pone.0007578. PMC 2762027. PMID 19855831. http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0007578. 

This organic chemistry article is a stub. You can help Wikipedia by expanding it.v · Categories: Quaternary ammonium compounds Organic chemistry stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно решить контрольную? Methiodal Methion Look at other dictionaries: methiodide — noun Any of a class of compounds, of general formula RC(CH)I, formed by the reaction of methyl iodide with an aldehyde or ketone …   Wiktionary methiodide — meth·iodide …   English syllables methiodide — mə̇th+ noun Etymology: meth + iodide : a compound with methyl iodide …   Useful english dictionary nicotinehydroxamic acid methiodide — An effective cholinesterase reactivator, with actions that are most marked at the skeletal neuromuscular junction; antidotal effects are less striking at autonomic effector sites and insignificant in the central nervous system …   Medical dictionary BMI — usually refers to:* Body mass index, a numerical computation regarding height and weightbut may also refer to:;Business * Baltimore Museum of Industry * BMI (airline), a United Kingdom airline * BMI Healthcare, a British healthcare company * Bank …   Wikipedia PAM — or PAM may refer to: Contents 1 Companies 2 Organisations 3 Military …   Wikipedia Bicuculline — drugbox IUPAC name = Bicuculline width = 200 height = 150 CAS number = 485 49 4 ATC prefix = ATC suffix = ATC supplemental = PubChem = 10237 DrugBank = smiles = C1=C6C(=CC2=C1CCN( [C@@H] 2 [C@H] 3C4C(C(O3)=O)C5=C(C=C4)OCO5)C)OCO6 C=20 | H=17 |… …   Wikipedia Pralidoxime — Systematic (IUPAC) name 2 [(hydroxyimino)m …   Wikipedia PAM — Acronym for potential acuity meter. * * * pancreatic acinar mass; penicillin aluminum monostearate; peptidylglycine alpha amidating monooxygenase; phenylalanine mustard; physical agent modality; physical archive manager [database element]; p… …   Medical dictionary ACÉTYLCHOLINE — L’acétylcholine (ACh) est l’ester acétique de la choline, corps basique azoté dérivé de l’ammonium quaternaire. Formule de l’acétylcholine: 廓 acétoxyéthyl triméthyl ammonium. L’ACh a été préparée par voie synthétique en 1867 et peut être obtenue… …   Encyclopédie Universelle 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”