DinI-like protein family

DinI-like protein family
DinI-like family
PDB 1ghh EBI.jpg
solution structure of dini
Symbol DinI
Pfam PF06183
InterPro IPR010391
SCOP 1ghh

In molecular biology, the DinI-like protein family is a family of short proteins. The family includes DNA-damage-inducible protein I (DinI) and related proteins. The SOS response, a set of cellular phenomena exhibited by eubacteria, is initiated by various causes that include DNA damage-induced replication arrest, and is positively regulated by the co-protease activity of RecA. Escherichia coli DinI, a LexA-regulated SOS gene product, shuts off the initiation of the SOS response when overexpressed in vivo. Biochemical and genetic studies indicated that DinI physically interacts with RecA to inhibit its co-protease activity.[1] The structure of DinI is known.[2]


  1. ^ Yoshimasu M, Aihara H, Ito Y, Rajesh S, Ishibe S, Mikawa T, Yokoyama S, Shibata T (March 2003). "An NMR study on the interaction of Escherichia coli DinI with RecA-ssDNA complexes". Nucleic Acids Res. 31 (6): 1735–43. doi:10.1093/nar/gkg256. PMC 152859. PMID 12626715. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=152859. 
  2. ^ Ramirez BE, Voloshin ON, Camerini-Otero RD, Bax A (November 2000). "Solution structure of DinI provides insight into its mode of RecA inactivation". Protein Sci. 9 (11): 2161–9. doi:10.1110/ps.9.11.2161. PMC 2144493. PMID 11152126. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2144493. 

This article includes text from the public domain Pfam and InterPro IPR010391

Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”