Diffuse lamellar keratitis
- Diffuse lamellar keratitis
-
Diffuse lamellar keratitis (DLK) is a sterile inflammation of the cornea which may occur after refractive surgery, such as LASIK.[1] Its incidence has been estimated to be 1 in 500 patients[2], though this may be as high as 32% in some cases[3].
Signs and symptoms
Patients typically present within one week of surgery with eye pain, photophobia, conjunctivitis, or excessive tear production.
Pathology
DLK is usually seen after refractive surgery. Neutrophils infiltrate the corneal stroma in a diffuse, multifocal pattern. Infiltration is confined to the surgical flap interface with no posterior or anterior extension, and overlying epithelium most often remains intact. As it is a sterile (non-infectious) condition microbiological cultures are negative.
Stages
There are 4 stages of disease, with stage 4 being the rarest and most severe.
Treatment
Depending on severity, therapies may range from topical or oral anti-inflammatories to irrigation and surgical repair.
References
Categories:
- Diseases of the eye and adnexa
- Eye stubs
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