Dental pulp stem cells

Dental pulp stem cells

Dental Pulp Stem Cells, or (DPSCs) are multipotent stem cells that have the potential to differentiate into a variety of cell types.

More recently a subpopulation of dental pulp stem cells has been described as human Immature Dental Pulp Stem Cells (IDPSC).[1]

Definition

Dental pulp is the soft living tissue inside a tooth. Stem cells are found inside the soft living tissue.[2] Scientists have identified the Mesenchymal type of stem cell inside dental pulp. This particular type of stem cell has the future potential to differentiate into a variety of other cell types including:

  • Cardio Myocytes to repair damaged cardiac tissue following a heart attack [3]
  • Neuronal to generate nerve and brain tissue[4]
  • Myocytes to repair muscle [5]
  • Osteocytes to generate bone [6][7]
  • Chondrocytes to generate cartilage[8]
  • Adipocytes to generate fat [8]
  • Bone and tissue from the oral cavity.[9]

History

  • 2003 NIH announces discovery of DPSCs by Dr. Songtao Shi [2]
  • 2006 IDPSC Kerkis reported discovery of Immature Dental Pulp Stem Cells (IDPSC),[1] a pluripotent sub-population of DPSC using dental pulp organ culture.
  • 2007 DPSC 1st animal studies begin for bone regeneration.[6][7]
  • 2007 DPSC 1st animal studies begin for dental end uses.[10][11]
  • 2008 DPSC 1st animal studies begin for heart therapies.[3]
  • 2008 IDPSC 1st animal study began for muscular dystrophy therapies.[5][5]
  • 2008 DPSC 1st animal studies begin for regenerating brain tissue.[4]
  • 2008 DPSC 1st advanced animal study for bone grafting announced. Reconstruction of large size cranial bone defects in rats.[9]
  • 2010 IDPSC 1st human trial for cornea replacement

References

  1. ^ a b Kerkis, Irina; Kerkis, Alexandre; Dozortsev, Dmitri; Stukart-Parsons, GaËlle Chopin; Gomes Massironi, SÍLvia Maria; Pereira, Lygia V.; Caplan, Arnold I.; Cerruti, Humberto F. (2006). "Isolation and Characterization of a Population of Immature Dental Pulp Stem Cells Expressing OCT-4 and Other Embryonic Stem Cell Markers". Cells Tissues Organs 184 (3–4): 105–16. doi:10.1159/000099617. PMID 17409736. 
  2. ^ a b National Institute of Health (NIH) press release Monday, April 21, 2003 http://www.nih.gov/news/pr/apr2003/nidcr-21.html[dead link]
  3. ^ a b Gandia, Carolina; Armiñan, Ana; García-Verdugo, Jose Manuel; Lledó, Elisa; Ruiz, Amparo; Miñana, M Dolores; Sanchez-Torrijos, Jorge; Payá, Rafael et al. (2008). "Human Dental Pulp Stem Cells Improve Left Ventricular Function, Induce Angiogenesis, and Reduce Infarct Size in Rats with Acute Myocardial Infarction". Stem Cells 26 (3): 638–45. doi:10.1634/stemcells.2007-0484. PMID 18079433. 
  4. ^ a b Nosrat, I; Widenfalk, J; Olson, L; Nosrat, CA (2001). "Dental Pulp Cells Produce Neurotrophic Factors, Interact with Trigeminal Neurons in Vitro, and Rescue Motoneurons after Spinal Cord Injury". Developmental Biology 238 (1): 120–32. doi:10.1006/dbio.2001.0400. PMID 11783998. [not in citation given]
  5. ^ a b c Kerkis, Irina; Ambrosio, Carlos E; Kerkis, Alexandre; Martins, Daniele S; Zucconi, Eder; Fonseca, Simone AS; Cabral, Rosa M; Maranduba, Carlos MC et al. (2008). "Early transplantation of human immature dental pulp stem cells from baby teeth to golden retriever muscular dystrophy (GRMD) dogs: Local or systemic?". Journal of Translational Medicine 6: 35. doi:10.1186/1479-5876-6-35. PMC 2529267. PMID 18598348. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2529267. 
  6. ^ a b Graziano, Antonio; D'aquino, Riccardo; Angelis, Maria Gabriella Cusella-De; De Francesco, Francesco; Giordano, Antonio; Laino, Gregorio; Piattelli, Adriano; Traini, Tonino et al. (2008). "Scaffold's surface geometry significantly affects human stem cell bone tissue engineering". Journal of Cellular Physiology 214 (1): 166–72. doi:10.1002/jcp.21175. PMID 17565721. 
  7. ^ a b D’aquino, Riccardo; Papaccio, Gianpaolo; Laino, Gregorio; Graziano, Antonio (2008). "Dental Pulp Stem Cells: A Promising Tool for Bone Regeneration". Stem Cell Reviews 4 (1): 21–6. doi:10.1007/s12015-008-9013-5. PMID 18300003. 
  8. ^ a b Stem Cell Information, National Institute of Health
  9. ^ a b . pp. 204–10. doi:10.1097/scs.0b013e31815c8a54. 
  10. ^ Onyekwelu, O; Seppala, M; Zoupa, M; Cobourne, MT (2007). "Tooth development: 2. Regenerating teeth in the laboratory". Dental update 34 (1): 20–2, 25–6, 29. PMID 17348555. 
  11. ^ Cordeiro, Mabel M.; Dong, Zhihong; Kaneko, Tomoatsu; Zhang, Zhaocheng; Miyazawa, Marta; Shi, Songtao; Smith, Anthony J.; Nör, Jacques E. (2008). "Dental Pulp Tissue Engineering with Stem Cells from Exfoliated Deciduous Teeth". Journal of Endodontics 34 (8): 962–9. doi:10.1016/j.joen.2008.04.009. PMID 18634928. 

Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • Stem cell — Mouse embryonic st …   Wikipedia

  • Dental caries — This article is about dental caries in humans. To read about dental caries in other animals, please see dental caries (non human). Dental caries Classification and external resources Destruction of a tooth by cervical decay from dental caries.… …   Wikipedia

  • Adult stem cell — Adult stem cells are undifferentiated cells found throughout the body after embryonic development that divide to replenish dying cells and regenerate damaged tissues. Also known as somatic (from Greek Σωματικóς, of the body ) stem cells, they can …   Wikipedia

  • Mesenchymal stem cell — showing typical ultrastructural morphology. Latin cellula mesenchymatica precursoria Code TH H2 …   Wikipedia

  • Tooth (human) — For other uses of tooth or teeth , see Tooth (disambiguation). Teeth An adult human s teeth …   Wikipedia

  • Tooth — Infobox Anatomy Name = Teeth Caption = An adult human s teeth. Caption2 = CGI posterior view of teeth taken from inside of mouthTeeth (singular, Tooth) are small whitish structures found in the jaws (or mouths) of many vertebrates that are used… …   Wikipedia

  • Odontoblast — A developing tooth with odontoblasts marked. The cervical loop area: (1) dental follic …   Wikipedia

  • Osteonecrosis of the jaw — Osteonecrosis of the jaws Classification and external resources Osteonecrosis of the jaw of the upper left jaw in a patient diagnosed with chronic venous insufficiency ICD 10 M …   Wikipedia

  • digestive system disease — Introduction       any of the diseases that affect the human digestive tract. Such disorders may affect the esophagus, stomach, small intestine, large intestine (colon), pancreas, liver, or biliary tract. A prevalent disorder of the digestive… …   Universalium

  • Wisdom tooth — A wisdom tooth, in humans, is any of the usually four third molars. Wisdom teeth usually appear between the ages of 17 and 25.[1] Most adults have four wisdom teeth, but it is possible to have more, in which case they are called supernumerary… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”