David A. Cheresh

David Cheresh is a Michigan-born scientist best known for his studies on angiogenesis and cancer metastasis. His early research focused on the function of integrins, cellular receptors for the extracellular matrix, in cell migration and survival. His current studies have focused on signaling aspects of cell invasion by vascular cells and tumor cells, with a focuses on preventing tumor metastasis.

After receiving a PhD in Immunology from the University of Miami in 1982, Dr. Cheresh moved to California to train with Ralph Reisfeld at The Scripps Research Institute in La Jolla in 1983, where he was later appointed assistant professor. In April 2005, Cheresh joined the Department of Pathology in the school of medicine at the University of California San Diego, and moved his laboratory to the Moores UCSD Cancer Center. Dr. Cheresh has been the recipient of numerous awards, including an NIH merit award from the division of cancer cell biology.

As of 2010, Dr. Cheresh is a Professor and Vice Chair of Research in the Department of Pathology in the School of Medicine at the University of California, San Diego.

Key publications

• Desgrosellier, J.S., Barnes, L.A., Shields, D.J., Huang, M., Lau, S.K., Prévost, N., Tarin, D., Shattil, S.J. and Cheresh, D.A. Integrin αvβ3/c-src “Oncogenic Unit” Promotes Anchorage-independence and Tumor Progression. 'Nature Medicine' Sept. 6, 2009.
• Greenberg, J.I., Shields, D.J., Barillas, S.G., Acevedo, L.M., Murphy, E., Huang, J., Scheppke, E., Stockmann, C., Johnson, R.S., Angle, N. and Cheresh, D.A. A role for VEGF as a negative regulator of pericyte function and vessel maturation. 'Nature' 456: 809-813, 2008.
• Stockmann, C., Doedens, A., Weidemann, A., Zhang, N., Takeda, N., Greenberg, J.I., Cheresh, D.A. and Johnson, R.S. Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. 'Nature' 456: 814-819, 2008.
• Murphy, E.A., Majeti, B.K., Barnes L., Makale, M., Weis, S.M., Wrasidlo, W., and Cheresh, D.A. Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis. 'Proc. Natl. Acad. Sci.' 105: 9343-9348, 2008.
• Stupack, D., Teitz,T., Potter,M., Mikolon,D., Kidd,V.J., Lahti,J.M., Cheresh,D.A. Potentiation of neuroblastoma metastasis by loss of caspase 8. 'Nature' 439:95-99, 2006.
• Alavi, A., Hood, J.D., Frausto, R., Stupack, D.G. & Cheresh, D.A. Role of Raf in vascular protection from distinct apoptotic stimuli. 'Science' 301:94-96, 2003.
• Eliceiri, B.P., Paul, R., Schwartzberg, P.L., Hood, J.D., Leng, J. and Cheresh, D.A. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permaeability. 'Molecular Cell' 4:915-924. 1999.
• Friedlander, M., Brooks, P.C., Shaffer, R.W., Kincaid, C.M., Varner, J.A., and Cheresh, D.A. Definition of two angiogenic pathways by distinct αv integrins. 'Science' 270:1500-1502, 1995
• Brooks, P.C., Montgomery, A.M.P., Rosenfeld, M., Reisfeld, R.A., Hu, T., Klier, G. and Cheresh, D.A. Integrin αvß3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. 'Cell' 79:1157-1164, 1994.

External links

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Name	Cheresh, David A.
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