DIS3L

DIS3 mitotic control homolog (S. cerevisiae)-like
Identifiers
Symbols	DIS3L; FLJ38088; KIAA1955; MGC4562
External IDs	MGI: 2143272 HomoloGene: 15797 GeneCards: DIS3L Gene
EC number	3.1.13.-
Gene Ontology Molecular function • RNA binding • exonuclease activity • ribonuclease activity • hydrolase activity Cellular component • exosome (RNase complex) • cytoplasm Biological process • rRNA catabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	115752	213550
Ensembl	ENSG00000166938	ENSMUSG00000032396
UniProt	Q8TF46	Q8C0S1
RefSeq (mRNA)	NM_001143688.1	NM_001001295
RefSeq (protein)	NP_001137160.1	NP_766107
Location (UCSC)	Chr 15: 66.59 – 66.63 Mb	Chr 9: 64.15 – 64.19 Mb
PubMed search	[1]	[2]

DIS3-like exonuclease 1 (Dis3L1 or Dis3L) is an enzyme that in humans is encoded by the DIS3L gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the cytoplasm of eukaryotic cells.^[1][2]

References

1. ^ Staals RH, Bronkhorst AW, Schilders G, Slomovic S, Schuster G, Heck AJ, Raijmakers R, Pruijn GJ (July 2010). "Dis3-like 1: a novel exoribonuclease associated with the human exosome". EMBO J. 29 (14): 2358–67. doi:10.1038/emboj.2010.122. PMC 2910272. PMID 20531389. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2910272. 
2. ^ Tomecki R, Kristiansen MS, Lykke-Andersen S, Chlebowski A, Larsen KM, Szczesny RJ, Drazkowska K, Pastula A, Andersen JS, Stepien PP, Dziembowski A, Jensen TH (July 2010). "The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L". EMBO J. 29 (14): 2342–57. doi:10.1038/emboj.2010.121. PMC 2910271. PMID 20531386. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2910271.