Human immunodeficiency virus type 1 stem-loop 3 Psi packaging signal

Human immunodeficiency virus type 1 stem-loop 3 Psi packaging signal

The Human immunodeficiency virus type 1 stem-loop 3 Psi packaging signal (HIV-1 SL3) is an RNA structure that is shown to facilitate HIV-1 mRNA packaging.

The HIV-1 SL3 structure consists of a highly conserved 14 nt stem-loop which was predicted within the HIV-1 5' untranslated leader and confirmed by mutagenesis and mass spectrometric detection (MS3D). HIV-1 SL3 is sufficient by itself to induce heterologous RNA into virus-like particles but its deletion does not completely eliminate encapsidation [cite journal| title= MS3D structural elucidation of the HIV-1 packaging signal.| id = PMID 18713870 ] . The Rfam structure is based on a covariation model.

This element forms part of a larger Retroviral Psi packaging element in the HIV genome.

References

ee also

Retroviral Psi packaging element

External links

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Look at other dictionaries:

  • Human immunodeficiency virus type 1 stem-loop 4 packaging signal — The Human immunodeficiency virus type 1 stem loop 4 packaging signal (HIV 1 SL4) is an RNA structure involved in facilitating HIV 1 RNA packaging.It also may have coding and non coding roles. The HIV 1 SL4 structure consists of a highly conserved …   Wikipedia

  • Retroviral Psi packaging element — is a cis acting RNA element identified in the genomes of the retroviruses Human immunodeficiency virus (HIV) and Simian immunodeficiency virus (SIV). It is involved in regulating encapsidation of the retroviral RNA, an essential step in… …   Wikipedia

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