Human immunodeficiency virus type 1 stem-loop 4 packaging signal
- Human immunodeficiency virus type 1 stem-loop 4 packaging signal
The Human immunodeficiency virus type 1 stem-loop 4 packaging signal (HIV-1 SL4) is an RNA structure involved in facilitating HIV-1 RNA packaging.
It also may have coding and non-coding roles. The HIV-1 SL4 structure consists of a highly conserved 14 nt stem-loop that is located downstream of the gag start codon. It was confirmed by mutagenesis and has an NMR and mass spectrometric detection (MS3D) structure. [cite journal| title= MS3D structural elucidation of the HIV-1 packaging signal.| id = PMID 18713870 ] . The Rfam structure is based on a covariation model.
This element forms part of a larger Retroviral Psi packaging element in the HIV genome.
References
ee also
Retroviral Psi packaging element
External links
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