Biphenylindanone A

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IUPAC_name = 3’-(((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy)methyl)biphenyl-4-carboxylic acid

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PubChem = 9868580
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C=30|H=30|O=4
molecular_weight = 454.556 g/mol
smiles = c3cc(C(O)=O)ccc3-c(ccc4)cc4COc(c1C)cc(c(C2=O)c1C)CC2C5CCCC5
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Biphenylindanone A (BINA, LS-193,571) is a research drug which acts as a potent and selective positive allosteric modulator for the group II metabotropic glutamate receptor subtype mGlu2. In animal studies it showed anxiolytic and antipsychotic effects, [Galici R, Jones CK, Hemstapat K, Nong Y, Echemendia NG, Williams LC, de Paulis T, Conn PJ. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. "Journal of Pharmacology and Experimental Therapeutics". 2006 Jul;318(1):173-85. PMID 16608916] and blocked the effects produced by the hallucinogenic drug DOB. BINA and other selective mGlu2 positive modulators have therefore been suggested as a novel class of drugs for the treatment of schizophrenia which may have superior properties to traditional antipsychotic drugs. [Benneyworth MA, Xiang Z, Smith RL, Garcia EE, Conn PJ, Sanders-Bush E. A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis. "Molecular Pharmacology". 2007 Aug;72(2):477-84. PMID 17526600]

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