Human immunodeficiency virus type 1 major splice donor

Human immunodeficiency virus type 1 major splice donor

The Human immunodeficiency virus type 1 major splice donor (HIV-1 SD) is an RNA structure that is shown to modulate splicing efficiency of HIV-1 mRNAs.

The HIV-1 SD structure consists of a highly conserved 19 nt stem-loop which was predicted within the HIV-1 5' untranslated leader and confirmed by mutagenesis. [cite journal| title= RNA structure modulates splicing efficiency at the human immunodeficiency virus type 1 major splice donor | id = PMID 18160437] .The Rfam structure is based on a covariation model.

This element forms part of a larger Retroviral Psi packaging element in the HIV genome.

References

ee also

Retroviral_Psi_packaging_element

External links

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  • Retroviral Psi packaging element — is a cis acting RNA element identified in the genomes of the retroviruses Human immunodeficiency virus (HIV) and Simian immunodeficiency virus (SIV). It is involved in regulating encapsidation of the retroviral RNA, an essential step in… …   Wikipedia

  • Alternative splicing — produces two protein isoforms. Alternative splicing (or differential splicing) is a process by which the exons of the RNA produced by transcription of a gene (a primary gene transcript or pre mRNA) are reconnected in multiple ways during RNA… …   Wikipedia

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