Bisphosphonate-associated osteonecrosis of the jaws
- Bisphosphonate-associated osteonecrosis of the jaws
Bisphosphonate-associated osteonecrosis of the jaws, often abbreviated as BON, is a recently discovered dental phenomenon that may lead to surgical complication in the form of impaired wound healing following oral or periodontal surgery or endodontic therapy. [Nase, JB & Suzuki, JB (2006), " [http://jada.ada.org/cgi/content/full/137/8/1115?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Osteonecrosis+of+the+Jaw+and+Oral+Bisphosphonate+Treatment&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT Osteonecrosis of the jaw and oral bisphosphonate treatment] ", "JADA" 137(8): 1115-1119]
Osteonecrosis, or localized death of bone tissue, of the jaws is a rare potential complication in cancer patients receiving treatments including radiation, chemotherapy, or in patients with tumors or infectious embolic events. In 2003, [Marx, RE (2003), Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. "J Oral Maxillofac Surg" 61:1115-1117] [Migliorati, CA (2003) Bisphosphonates and oral cavity avascular bone necrosis. "J Clin Oncol" 21:4253-4254.] reports surfaced of the increased risk of osteonecrosis in patients receiving these therapies concomitantant with and an intravenous bisphosphonate. [ [http://www.fda.gov/ohrms/dockets/ac/05/briefing/2005-4095B2_02_12-Novartis-Zometa-App-11.htm Appendix 11: Expert Panel Recommendation for the Prevention, Diagnosis and Treatment of Osteonecrosis of the Jaw] ]
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