- HHAT
protein
Name=hedgehog acyltransferase
caption=
width=
HGNCid=18270
Symbol=HHAT
AltSymbols=FLJ10724, MART-2, MART2, GUP2
EntrezGene=55733
OMIM=605743
RefSeq=NM_018194
UniProt= Q5VTY9
PDB=
ECnumber=2.3.1.-
Chromosome=1
Arm=q
Band=32
LocusSupplementaryData=HHAT (hedgehog acyltransferase) also known as HHAT is a human
gene .cite journal | author = Kawakami Y, Wang X, Shofuda T, Sumimoto H, Tupesis J, Fitzgerald E, Rosenberg S | title = Isolation of a new melanoma antigen, MART-2, containing a mutated epitope recognized by autologous tumor-infiltrating T lymphocytes | journal = J. Immunol. | volume = 166 | issue = 4 | pages = 2871–7 | year = 2001 | month = February | pmid = 11160356 | doi = | url = http://www.jimmunol.org/cgi/content/abstract/166/4/2871 | issn = ]The HHAT gene encodes an
enzyme that catalyzes N-terminalpalmitoylation ofsonic hedgehog . Mutations in HHAT produce aphenotype that is similar to loss of hedgehog function. Finally the HHAT protein shares a short but significant sequence similarity to membrane-bound O-acyltransferases .cite journal | author = Chamoun Z, Mann RK, Nellen D, von Kessler DP, Bellotto M, Beachy PA, Basler K | title = Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal | journal = Science (journal) | volume = 293 | issue = 5537 | pages = 2080–4 | year = 2001 | month = September | pmid = 11486055 | doi = 10.1126/science.1064437 | url = | issn = ]Refences
External links
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