Geiparvarin

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ImageFile=Geiparvarin.svg
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IUPACName=7-{ [(2"E")-3-(5,5-dimethyl-4-oxo-4,5-dihydrofuran- 2-yl)but-2-en-1-yl] oxy}-2"H"-chromen-2-one
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Section1=Chembox Identifiers
CASNo=36413-91-9
PubChem=5910585
SMILES=CC(=CCOC1=CC2=C(C=C1)C=CC(=O)O2)C3=CC(=O)C(O3)(C)C
MeSHName=Geiparvarin
Section2=Chembox Properties
Formula=C₁₉H₁₈O₅
MolarMass=326.343 g/mol
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Geiparvarin is a coumarin derivative found in the leaves of the Australian Willow ("Geijera parviflora"). [cite journal |author=Lahey FN, Macleod JK |title=The coumarins of "Geijera parviflora" Lindl |journal=Aust J Chem |volume=20 |issue=9 |pages=1943–55 |month=September |year=1967 |doi=10.1071/CH9671943] It is a monoamine oxidase inhibitor.cite journal |author=Carotti A, Carrieri A, Chimichi S, "et al" |title=Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies |journal=Bioorg. Med. Chem. Lett. |volume=12 |issue=24 |pages=3551–5 |year=2002 |month=December |pmid=12443774 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/S0960894X02007989]

Several analogues of geiparvarin have been studied for antitumor properties. [cite journal |author=Baraldi PG, Guarneri M, Manfredini S, Simoni D, Balzarini J, De Clercq E |title=Synthesis and cytostatic activity of geiparvarin analogues |journal=J Med Chem |volume=32 |issue=2 |pages=284–8 |year=1989 |month=February |pmid=2913291 |doi= |url=] [cite journal |author=Valenti P, Rampa A, Recanatini M, "et al" |title=Synthesis, cytotoxicity and SAR of simple geiparvarin analogues |journal=Anticancer Drug Des |volume=12 |issue=6 |pages=443–51 |year=1997 |month=September |pmid=9311554 |doi= |url=] [cite journal |author=Viola G, Vedaldi D, dall'Acqua F, "et al" |title=Synthesis, cytotoxicity, and apoptosis induction in human tumor cells by geiparvarin analogues |journal=Chem Biodivers |volume=1 |issue=9 |pages=1265–80 |year=2004 |month=September |pmid=17191904 |doi=10.1002/cbdv.200490089 |url=]

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