Pseudoangiomatous stromal hyperplasia

In breast pathology, pseudoangiomatous stromal hyperplasia, commonly abbreviated PASH, is an overgrowth of myofibroblastic cells and has an appearance similar to fibroadenomatoid changes.cite journal |author=Powell CM, Cranor ML, Rosen PP |title=Pseudoangiomatous stromal hyperplasia (PASH). A mammary stromal tumor with myofibroblastic differentiation |journal=Am. J. Surg. Pathol. |volume=19 |issue=3 |pages=270–7 |year=1995 |month=March |pmid=7872425 |doi= |url=] The diagnostic significance is currently uncertain, but it appears to be benign.

Its important differential diagnosis is angiosarcoma, from which it was first differentiated in 1986. [cite journal |author=Vuitch MF, Rosen PP, Erlandson RA |title=Pseudoangiomatous hyperplasia of mammary stroma |journal=Hum. Pathol. |volume=17 |issue=2 |pages=185–91 |year=1986 |month=February |pmid=3949338 |doi= |url=]

Diagnosis

The diagnosis of PASH is by biopsy.

Differential diagnosis

*Fibroadenoma
*Angiosarcoma [cite journal |author=de Saint Aubain Somerhausen N, Larsimont D, Cluydts N, Heymans O, Verhest A |title=Pseudoangiomatous hyperplasia of mammary stroma in an HIV patient |journal=Gen Diagn Pathol |volume=143 |issue=4 |pages=251–4 |year=1997 |month=December |pmid=9489960 |doi= |url=]

Treatment

The management of PASH is surgical excision.

References

External links

* [http://www.thedoctorsdoctor.com/diseases/breast_pash.htm Literature on PASH] - thedoctorsdoctor.com.
* [http://www.nature.com/modpathol/journal/v21/n2/fig_tab/3801003f1.html Micrographs of PASH] - nature.com.