Ventricular remodeling

Ventricular remodeling

Ventricular remodeling refers to the changes in size, shape, and function of the heart after injury to the left ventricle. The injury is typically due to acute myocardial infarction (usually transmural or ST segment elevation infarction), but may be from a number of causes that result in increased pressure or volume overload (forms of strain) on the heart. Chronic hypertension, congenital heart disease with intracardiac shunting, and valvular heart disease may also lead to remodeling. After the insult occurs, a series of histopathological and structural changes occur in the left ventricular myocardium that lead to progressive decline in left ventricular performance. Ultimately, ventricular remodeling may result in diminished contractile (systolic) function and reduced stroke volume.

Medically speaking, "ventricular remodeling" implies a decline in function (even though the word "remodeling" usually implies improvement). The term "reverse remodeling" in cardiology implies an improvement in ventricular mechanics and function after a remote injury.


The cardiac myocyte is the major cell involved in remodeling. Fibroblasts, collagen, the interstitium, and the coronary vessels to a lesser extent, also play a role. A common scenario for remodeling is after myocardial infarction. There is myocardial necrosis (cell death) and disproportionate thinning of the heart. This thin, weakened area is unable to withstand the pressure and volume load on the heart in the same manner as the other healthy tissue. As a result there is dilatation of the chamber arising from the infarct region. The initial remodeling phase after a myocardial infarction results in repair of the necrotic area and scar formation that may, to some extent, be considered beneficial since there is an improvement in or maintenance of LV function and cardiac output. Over time, however, as the heart undergoes ongoing remodeling, it becomes less elliptical and more spherical. Ventricular mass and volume increase, which together adversely affect cardiac function. Eventually, diastolic function, or the heart's ability to relax between contractions may become impaired, further causing decline.


Many factors influence the time course and extent of remodeling, including the severity of the insult, secondary events (recurrent ischemia or infarction), neurohormonal activation, genetic factors and gene expression, and treatment. Medications may attenuate remodeling. Angiotensin-converting enzyme (ACE) inhibitors have been consistently shown to decrease remodeling in animal models or transmural infarction and chronic pressure overload. Clinical trials have shown that ACE inhibitor therapy after myocardial infarction leads to improved myocardial performance, improved ejection fraction, and decreased mortality compared to patients treated with placebo. Likewise, inhibition of aldosterone, either directly or indirectly, leads to improvement in remodeling. [ [ NEJM - Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction ] ] Early correction of congenital heart defects, if appropriate, may prevent remodeling, as will treatment of chronic hypertension or valvular heart disease. Often, reverse remodeling, or improvement in left ventricular function, will also be seen.

ee also



(1) Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003; 348:1309-21. (

*Cardiac remodeling--concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol. 2000 Mar 1;35(3):569-82.

*Sutton, MG, Sharpe, N. Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation 2000; 101:2981

*Konstam, MA, Kronenberg, MW, Rousseau, MF, et al. Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dilatation in patients with asymptomatic systolic dysfunction. SOLVD (Studies of Left Ventricular Dysfunction) Investigators. Circulation 1993; 88:2277.

*Greenberg, B, Quinones, MA, Koilpillai, C, et al. Effects of long-term enalapril therapy on cardiac structure and function in patients with left ventricular dysfunction. Results of the SOLVD echocardiography substudy. Circulation 1995; 91:2573.

*Doughty, RN, Whalley, GA, Gamble, G, et al. Left ventricular remodeling with carvedilol in patients with congestive heart failure due to ischemic heart disease. J Am Coll Cardiol 1997; 29:1060.

*Kheradvar, A, Gorman, RC, Gorman, JH 3rd, Zeeshan, A, Gharib, M. Evaluation of isovolumic relaxation phase in the process of ventricular remodeling following myocardial infarction. Conf Proc IEEE Eng Med Biol Soc. 2004;5:3654-7.

*Cohn JN. Cardiac Remodeling, UpToDate v.13.1 Accessed July 17, 2005.

Wikimedia Foundation. 2010.

Нужно решить контрольную?

Look at other dictionaries:

  • ventricular remodeling — the most common type of cardiac remodeling, usually in the left ventricle …   Medical dictionary

  • Ventricular septal defect — Infobox Disease Name = PAGENAME Caption = Echocardiographic image of a moderate ventricular septal defect in the mid muscular part of the septum. The trace in the lower left shows the flow during one complete cardiac cycle and the red mark the… …   Wikipedia

  • cardiac remodeling — geometric and structural changes in heart chambers, usually ventricles, with decline in function that can lead to heart failure; the most common cause is cardiomyopathy, such as from the strain of hypertension or following myocardial infarction.… …   Medical dictionary

  • Dilated cardiomyopathy — Classification and external resources ICD 10 I42.0 ICD 9 425.4 …   Wikipedia

  • Management of heart failure — requires a muitimodal approach. It involves a combination of lifestyle modifications, medications, and possibly the use of devices or surgery. Contents 1 Diet and lifestyle measures 1.1 Fluid restriction 2 Pharmacological management …   Wikipedia

  • Dor procedure — In 1985, Vincent Dor, MD, introduced endoventricular circular patch plasty (EVCPP), or the Dor procedure, as a viable method for restoring a dilated left ventricle to its normal, elliptical geometry. The Dor procedure, which uses a circular… …   Wikipedia

  • cardiovascular disease — Introduction       any of the diseases, whether congenital or acquired, of the heart and blood vessels (blood vessel). Among the most important are atherosclerosis, rheumatic heart disease, and vascular inflammation. Cardiovascular diseases are a …   Universalium

  • ACE inhibitor — ACE inhibitors, or inhibitors of Angiotensin Converting Enzyme, are a group of pharmaceuticals that are used primarily in treatment of hypertension and congestive heart failure, in some cases as the drugs of first choice.Clinical useIndications… …   Wikipedia

  • Cardiac cycle — Cardiac events occurring in the cardiac cycle. Two complete cycles are illustrated. The cardiac cycle is a term referring to all or any of the events related to the flow or blood pressure that occurs from the beginning of one heartbeat to the… …   Wikipedia

  • Diastolic heart failure — Diastolic dysfunction Classification and external resources ICD 9 428.3 Diastolic heart failure or diastolic dysfunction refers to decline in performance of one or both ventricles of the heart during the time phase of diastole. Diastole is that… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”