CHRNA10

protein
Name = cholinergic receptor, nicotinic, alpha 10
caption =


width =
HGNCid = 13800
Symbol = CHRNA10
AltSymbols =
EntrezGene = 57053
OMIM = 606372
RefSeq = NM_020402
UniProt = Q9GZZ6
PDB =
ECnumber =
Chromosome = 11
Arm = p
Band = 15.5
LocusSupplementaryData =

Cholinergic receptor, nicotinic, alpha 10, also known as CHRNA10, is a human gene.cite journal | author = Lustig LR, Peng H, Hiel H, Yamamoto T, Fuchs PA | title = Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10) | journal = Genomics | volume = 73 | issue = 3 | pages = 272–83 | year = 2001 | month = May | pmid = 11350119 | doi = 10.1006/geno.2000.6503 | url = | issn = ] The protein encoded by this gene is a subunit of the nicotinic acetylcholine receptor (nAchR).

This nAchR subunit is required for the normal function of the olivocochlear system which is part of the auditory system.cite journal | author = Vetter DE, Katz E, Maison SF, Taranda J, Turcan S, Ballestero J, Liberman MC, Elgoyhen AB, Boulter J | title = The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 104 | issue = 51 | pages = 20594–9 | year = 2007 | month = December | pmid = 18077337 | pmc = 2154476 | doi = 10.1073/pnas.0708545105 | url = | issn = ] Furthermore selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.cite journal | author = Vincler M, Wittenauer S, Parker R, Ellison M, Olivera BM, McIntosh JM | title = Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 47 | pages = 17880–4 | year = 2006 | month = November | pmid = 17101979 | pmc = 1635975 | doi = 10.1073/pnas.0608715103 | url = | issn = ]

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