[cite web | title = Entrez Gene: CHRNA9 cholinergic receptor, nicotinic, alpha 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55584| accessdate = ] ] PBB_Summary
section_title =
summary_text = This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. The protein is additionally expressed in keratinocytes, the pituitary gland, B-cells and T-cells.[cite web | title = Entrez Gene: CHRNA9 cholinergic receptor, nicotinic, alpha 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55584| accessdate = ] ]
Selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.[cite journal | author = Vincler M, Wittenauer S, Parker R, Ellison M, Olivera BM, McIntosh JM | title = Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 47 | pages = 17880–4 | year = 2006 | month = November | pmid = 17101979 | pmc = 1635975 | doi = 10.1073/pnas.0608715103 | url = | issn = ] ]ee also
* Nicotinic acetylcholine receptor
References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Nguyen VT, Ndoye A, Grando SA |title=Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity. |journal=Am. J. Pathol. |volume=157 |issue= 4 |pages= 1377–91 |year= 2000 |pmid= 11021840 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Sgard F, Charpantier E, Bertrand S, "et al." |title=A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. |journal=Mol. Pharmacol. |volume=61 |issue= 1 |pages= 150–9 |year= 2002 |pmid= 11752216 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lustig LR, Peng H |title=Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene. |journal=Cytogenet. Genome Res. |volume=98 |issue= 2-3 |pages= 154–9 |year= 2003 |pmid= 12697997 |doi= 10.1159/000069804
*cite journal | author=Valor LM, Castillo M, Ortiz JA, Criado M |title=Transcriptional regulation by activation and repression elements located at the 5'-noncoding region of the human alpha9 nicotinic receptor subunit gene. |journal=J. Biol. Chem. |volume=278 |issue= 39 |pages= 37249–55 |year= 2003 |pmid= 12860975 |doi= 10.1074/jbc.M307043200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Peng H, Ferris RL, Matthews T, "et al." |title=Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes. |journal=Life Sci. |volume=76 |issue= 3 |pages= 263–80 |year= 2004 |pmid= 15531379 |doi= 10.1016/j.lfs.2004.05.031
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466
*cite journal | author=Chernyavsky AI, Arredondo J, Vetter DE, Grando SA |title=Central role of alpha9 acetylcholine receptor in coordinating keratinocyte adhesion and motility at the initiation of epithelialization. |journal=Exp. Cell Res. |volume=313 |issue= 16 |pages= 3542–55 |year= 2007 |pmid= 17706194 |doi= 10.1016/j.yexcr.2007.07.011
External links
*
PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes
