Malotilate

Malotilate
Malotilate
Systematic (IUPAC) name
diisopropyl 1,3-dithiol-2-ylidenemalonate
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status ℞ Prescription only
Routes Oral
Identifiers
CAS number 59937-28-9 N
ATC code None
PubChem CID 4006
UNII RV59PND975 YesY
ChEMBL CHEMBL1697754 N
Chemical data
Formula C12H16O4S2 
Mol. mass 288.38 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Malotilate (INN) is a drug used in the treatment of liver disease. It has been shown to facilitate liver regeneration in rats.[1]

References

  1. ^ Niwano et al, Acceleration of Liver Regeneration by Malotilate in Partially Hepatectomized Rats
  • Bührer M, Le Cotonnec JY, Wermeille M, Bircher J (1986). "Treatment of liver disease with malotilate. A pharmacokinetic and pharmacodynamic phase II study in cirrhosis". Eur. J. Clin. Pharmacol. 30 (4): 407–16. doi:10.1007/BF00607952. PMID 3743616. 
  • Siegers CP, Pauli V, Korb G, Younes M (August 1986). "Hepatoprotection by malotilate against carbon tetrachloride-alcohol-induced liver fibrosis". Agents Actions 18 (5–6): 600–3. doi:10.1007/BF01964970. PMID 3766314. 
  • Younes M, Siegers CP (May 1985). "Effect of malotilate on paracetamol-induced hepatotoxicity". Toxicol. Lett. 25 (2): 143–6. doi:10.1016/0378-4274(85)90074-8. PMID 4002245. 



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