Rs1805054

Infobox Single nucleotide polymorphism
rsid = 1805054
name_1 = C267T
name_2 = 267T/C
gene = HTR6
chromosome = 1
alzgene_geneid = 69
alzgene_polyid = 153 In genetics, Rs1805054, also called C267T, is a name used for a specific genetic variation, a single nucleotide polymorphism (SNP), in the HTR6 gene.It is one of the few investigated polymorphisms of its gene.C267T is a synonymous polymorphism.

As of 2008 meta-analysis of the polymorphism and Alzheimer's disease indicates that there probably is no association between the two, [Cite web
title = META-ANALYSIS OF ALL PUBLISHED AD ASSOCIATION STUDIES (CASE-CONTROL ONLY) rs1805054
url = http://www.alzforum.org/res/com/gen/alzgene/meta.asp?geneID=69&polyID=153
publisher = Alzheimer Research Forum
accessdate = 2008-07-04] though individual studies report such an association, e.g., a Chinese study found an association with late-onset Alzheimer's disease. [Cite journal
author = Rui Kan, Binbin Wang, Chuanfang Zhang, Ze Yang, Shun Ji, Zeping Lu, Chenguang Zheng, Feng Jin & Li Wang
title = Association of the HTR6 polymorphism C267T with late-onset Alzheimer's disease in Chinese
journal = Neuroscience Letters
volume = 372
issue = 1
pages = 27–29
year = 2004
month = November
doi = 10.1016/j.neulet.2004.09.007
pmid = 15531082] Another reported association in neuropsychiatry disorders is with treatment response in depression. [Cite journal
author = Seung-Hwan Lee, Kang-Joon Lee, Heon-Jeong Lee, Byung-Joo Ham, Seung-Ho Ryu & Min-Soo Lee
title = Association between the 5-HT6 receptor C267T polymorphism and response to antidepressant treatment in major depressive disorder
journal = Psychiatry and Clinical Neurosciences
volume = 59
issue = 2
pages = 140–145
year = 2005
month = April
doi = 10.1111/j.1440-1819.2005.01348.x
pmid = 15823158]

C267T has also been examined in relation to personality traits, with a Korean study finding some evidence for an association with the trait "self-transcendence". [Cite journal
author = Byung-Joo Ham, Yong-Ho Kim, Myung-Jin Choi, Ji-Hyun Cha, Yun-Kyeung Choi & Min-Soo Lee
title = Serotonergic genes and personality traits in the Korean population
journal = Neuroscience Letters
volume = 354
issue = 1
pages = 2–5
year = 2004
month = January
pmid = 14698468] A Japanese study reported no association with personality traits using the NEO PI-R personality inventory. [Cite journal
author = Mamoru Tochigi, Hiroyuki Hibino, Takeshi Otowa, Toshiyuki Ohtani, Takashi Ebisawa, Nobumasa Kato & Tsukasa Sasaki
title = No association of 5-HT2C, 5-HT6, and tryptophan hydroxylase-1 gene polymorphisms with personality traits in the Japanese population
journal = Neuroscience Letters
volume = 403
issue = 1-2
pages = 100–102
year = 2006
month = July
doi = 10.1016/j.neulet.2006.04.020
pmid = 16682118]

References