Anchoring fibrils

Anchoring fibrils

Anchoring fibrils (composed largely of type VII collagen) extend from the basal lamina of epithelial cells and attach to the lamina reticularis (also known as the reticular lamina) by wrapping around the reticular fiber (collagen III) bundles. The basal lamina and lamina reticularis together make up the basement membrane. Anchoring fibrils are essential to the functional integrity of the dermoepidermal junction.

Epidermolysis bullosa dystrophica

Epidermolysis bullosa dystrophica, also known as Dystrophic EB (DEB) is a chronic skin condition caused when anchoring fibrils are abnormal, diminished, or absent. This causes a weak dermoepidermal junction, where the epidermis easily separates from the dermis causing much pain. This condition is caused by a genetic defect coding for anchoring fibrils.

See Also

*Epidermis (skin)
*Dermis
*Lamina propria
*Connective tissue

References

*Sigrid Regauer, Gregory R. Seiler, Yann Barrandon, Karen W. Easley, Carolyn C. Compton. "Epithelial origin of cutaneous anchoring fibrils." J Cell Biol. 1990 November 1; 111(5): 2109–2115.

*Douglas R. Keene, Lynn Y. Sakai, Gregory P. Lunstrum, Nicholas P. Morris, Robert E. Burgeson. "Type VII collagen forms an extended network of anchoring fibrils." J Cell Biol. 1987 March 1; 104(3): 611–621.

*Bruckner-Tuderman L. "Biology of anchoring fibrils: lessons from dystrophic epidermolysis bullosa." Matrix Biology. 1999 February 1; 18(1): 43-54.

*Burgeson, R. E. "Type VII collagen, anchoring fibrils, and epidermolysis bullosa." Journal of investigative dermatology. 1993 October 28; 101(3): 252-255. [http://cat.inist.fr/?aModele=afficheN&cpsidt=4900196 Link]

*McGrath J. A., Ishida-Yamamoto A., O'Grady A., Leigh I. M., Eady R. A. J. "Structural variations in anchoring fibrils in dystrophic epidermolysis bullosa: correlation with type VII collagen expression." Journal of investigative dermatology. 1993 March 4; 100(4): 366-372. [http://cat.inist.fr/?aModele=afficheN&cpsidt=4680348 Link]

External links

* [http://www.thedoctorsdoctor.com/bodysites/skin_bm.htm Skin Basement Membrane]


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • Collagen — Tropocollagen triple helix Collagen /ˈkɒlədʒɨn/ is a group of naturally occurring proteins found in animals, especially in the flesh and connective tissues of mammals.[1] It is the main component of connectiv …   Wikipedia

  • Basement membrane — Illustration depicting basement membrane in relation to epithelium and endothelium. Also seen are other extracellular matrix components Latin membr …   Wikipedia

  • Fibril — The diminutive of fiber. A small fiber, a fine thread. * * * A minute fiber or component of a fiber. SYN: fibrilla. [Mod. L. fibrilla] anchoring fibrils collagen fibrils that insert in to the basal lamina of the epidermis and bind it down to the… …   Medical dictionary

  • Hemidesmosome — Hemidesmosomes (HD) are very small stud or rivet like structures on the inner basal surface of keratinocytes in the epidermis of skin. They are similar in form to desmosomes when visualized by electron microscopy. While desmosomes link two cells… …   Wikipedia

  • Basal lamina — The basal lamina is a layer of extracellular matrix on which epithelium sits and which is secreted by the epithelial cells. It is often confused with the basement membrane, and sometimes used inconsistently in the literature, see below.It is… …   Wikipedia

  • Epidermolysis bullosa dystrophica — Infobox Disease Name = PAGENAME Caption =An eighteen month old toddler with DEB. DiseasesDB = 29580 ICD10 = ICD10|Q|81|2|q|80 ICD9 = ICD9|757.39 ICDO = OMIM = 131750 MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = D016108 Epidermolysis… …   Wikipedia

  • locomotion — /loh keuh moh sheuhn/, n. the act or power of moving from place to place. [1640 50; see LOCOMOTIVE, MOTION] * * * Any of various animal movements that result in progression from one place to another. Locomotion is classified as either… …   Universalium

  • cell — cell1 cell like, adj. /sel/, n. 1. a small room, as in a convent or prison. 2. any of various small compartments or bounded areas forming part of a whole. 3. a small group acting as a unit within a larger organization: a local cell of the… …   Universalium

  • flagellar rootlet — one of the delicate striated fibrils of the flagellar root system that arise from the basal body and run deep into the cytoplasm, perhaps serving as anchoring organelles or having a skeletal function. They occur most commonly in phytoflagellate… …   Medical dictionary

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”