OSBPL2

OSBPL2
Oxysterol binding protein-like 2
Identifiers
Symbols OSBPL2; FLJ20223; KIAA0772; MGC4307; MGC8342; ORP-2; ORP2
External IDs OMIM606731 MGI2442832 HomoloGene77324 GeneCards: OSBPL2 Gene
RNA expression pattern
PBB GE OSBPL2 209221 s at tn.png
PBB GE OSBPL2 209222 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9885 228983
Ensembl ENSG00000130703 ENSMUSG00000039050
UniProt Q9H1P3 Q3TDA1
RefSeq (mRNA) NM_014835.2 NM_144500.3
RefSeq (protein) NP_055650.1 NP_653083.2
Location (UCSC) Chr 20:
60.81 – 60.87 Mb
Chr 2:
179.85 – 179.9 Mb
PubMed search [1] [2]

Oxysterol-binding protein-related protein 2 is a protein that in humans is encoded by the OSBPL2 gene.[1][2][3]

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.[3]

References

  1. ^ Laitinen S, Olkkonen VM, Ehnholm C, Ikonen E (Feb 2000). "Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism". J Lipid Res 40 (12): 2204–11. PMID 10588946. 
  2. ^ Laitinen S, Lehto M, Lehtonen S, Hyvarinen K, Heino S, Lehtonen E, Ehnholm C, Ikonen E, Olkkonen VM (Feb 2002). "ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism". J Lipid Res 43 (2): 245–55. PMID 11861666. 
  3. ^ a b "Entrez Gene: OSBPL2 oxysterol binding protein-like 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9885. 

Further reading


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Look at other dictionaries:

  • Oxysterol-binding protein — Crystallographic structure of the oxysterol binding protein (rainbow color cartoon, N terminus = blue, C terminus = red) bound to 7 hydroxycholesterol (stick diagram, carbon = white, oxygen = red).[1] …   Wikipedia

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