P4HA1

P4HA1
Prolyl 4-hydroxylase, alpha polypeptide I

PDB rendering based on 1tjc.
Identifiers
Symbols P4HA1; 4-PH alpha-1; P4HA
External IDs OMIM176710 MGI97463 HomoloGene30998 GeneCards: P4HA1 Gene
EC number 1.14.11.2
RNA expression pattern
PBB GE P4HA1 207543 s at tn.png
PBB GE P4HA1 212537 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5033 18451
Ensembl ENSG00000122884 ENSMUSG00000019916
UniProt P13674 Q3TN84
RefSeq (mRNA) NM_000917.3 NM_011030.2
RefSeq (protein) NP_000908.2 NP_035160.1
Location (UCSC) Chr 10:
74.77 – 74.86 Mb
Chr 10:
58.79 – 58.84 Mb
PubMed search [1] [2]

Prolyl 4-hydroxylase subunit alpha-1 is an enzyme that in humans is encoded by the P4HA1 gene.[1][2]

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.[2]

References

Further reading


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Look at other dictionaries:

  • Prolyl-4-Hydroxylase — Die Prolyl 4 Hydroxylase (4 PH) (auch: Procollagenprolin Dioxygenase) ist ein Enzymkomplex in Wirbeltieren, der die Hydroxylierung von Prolylresten in Proteinen katalysiert. Dabei handelt es sich um eine posttranslationale Modifikation. Sie ist… …   Deutsch Wikipedia

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