ACF (gene)

ACF (gene)

Apobec-1 complementation factor, also known as ACF, is a human gene.cite web | title = Entrez Gene: ACF apobec-1 complementation factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29974| accessdate = ]

PBB_Summary
section_title =
summary_text = Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined.cite web | title = Entrez Gene: ACF apobec-1 complementation factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29974| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chester A, Scott J, Anant S, Navaratnam N |title=RNA editing: cytidine to uridine conversion in apolipoprotein B mRNA. |journal=Biochim. Biophys. Acta |volume=1494 |issue= 1-2 |pages= 1–13 |year= 2000 |pmid= 11072063 |doi=
*cite journal | author=Mehta A, Kinter MT, Sherman NE, Driscoll DM |title=Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1846–54 |year= 2000 |pmid= 10669759 |doi=
*cite journal | author=Lellek H, Kirsten R, Diehl I, "et al." |title=Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19848–56 |year= 2000 |pmid= 10781591 |doi= 10.1074/jbc.M001786200
*cite journal | author=Yang Y, Sowden MP, Smith HC |title=Induction of cytidine to uridine editing on cytoplasmic apolipoprotein B mRNA by overexpressing APOBEC-1. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 22663–9 |year= 2000 |pmid= 10833526 |doi= 10.1074/jbc.M910406199
*cite journal | author=Blanc V, Navaratnam N, Henderson JO, "et al." |title=Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing. |journal=J. Biol. Chem. |volume=276 |issue= 13 |pages= 10272–83 |year= 2001 |pmid= 11134005 |doi= 10.1074/jbc.M006435200
*cite journal | author=Harrington JJ, Sherf B, Rundlett S, "et al." |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440–5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107
*cite journal | author=Lau PP, Chang BH, Chan L |title=Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome. |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 4 |pages= 977–83 |year= 2001 |pmid= 11352648 |doi= 10.1006/bbrc.2001.4679
*cite journal | author=Blanc V, Henderson JO, Kennedy S, Davidson NO |title=Mutagenesis of apobec-1 complementation factor reveals distinct domains that modulate RNA binding, protein-protein interaction with apobec-1, and complementation of C to U RNA-editing activity. |journal=J. Biol. Chem. |volume=276 |issue= 49 |pages= 46386–93 |year= 2002 |pmid= 11571303 |doi= 10.1074/jbc.M107654200
*cite journal | author=Anant S, Henderson JO, Mukhopadhyay D, "et al." |title=Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor. |journal=J. Biol. Chem. |volume=276 |issue= 50 |pages= 47338–51 |year= 2002 |pmid= 11577082 |doi= 10.1074/jbc.M104911200
*cite journal | author=Henderson JO, Blanc V, Davidson NO |title=Isolation, characterization and developmental regulation of the human apobec-1 complementation factor (ACF) gene. |journal=Biochim. Biophys. Acta |volume=1522 |issue= 1 |pages= 22–30 |year= 2001 |pmid= 11718896 |doi=
*cite journal | author=Xu XR, Huang J, Xu ZG, "et al." |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089–94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398
*cite journal | author=Dance GS, Sowden MP, Cartegni L, "et al." |title=Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 12703–9 |year= 2002 |pmid= 11815617 |doi= 10.1074/jbc.M111337200
*cite journal | author=Mehta A, Driscoll DM |title=Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing. |journal=RNA |volume=8 |issue= 1 |pages= 69–82 |year= 2002 |pmid= 11871661 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chester A, Somasekaram A, Tzimina M, "et al." |title=The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay. |journal=EMBO J. |volume=22 |issue= 15 |pages= 3971–82 |year= 2003 |pmid= 12881431 |doi= 10.1093/emboj/cdg369
*cite journal | author=Blanc V, Kennedy S, Davidson NO |title=A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling. |journal=J. Biol. Chem. |volume=278 |issue= 42 |pages= 41198–204 |year= 2003 |pmid= 12896982 |doi= 10.1074/jbc.M302951200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Xie K, Sowden MP, Dance GS, "et al." |title=The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 21 |pages= 8114–9 |year= 2004 |pmid= 15148397 |doi= 10.1073/pnas.0400493101
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • Chat Persan — Persan (chat)  Ne doit pas être confondu avec Shah d Iran. Pour les articles homonymes, voir Persan (homonymie) …   Wikipédia en Français

  • Chat persan — Persan (chat)  Ne doit pas être confondu avec Shah d Iran. Pour les articles homonymes, voir Persan (homonymie) …   Wikipédia en Français

  • Persan (chat) — Pour les articles homonymes, voir Persan (homonymie).  Ne doit pas être confondu avec Shah d Iran. Pe …   Wikipédia en Français

  • Mau égyptien — blac …   Wikipédia en Français

  • Kindesmißhandlung — Kindesmisshandlung ist Gewalt gegen Kinder oder Jugendliche. Es handelt sich um eine besonders schwere Form der Verletzung des Kindeswohls. Unter dem Begriff Kindesmisshandlung werden physische als auch psychische Gewaltakte, sexueller Missbrauch …   Deutsch Wikipedia

  • Kindsmissbrauch — Kindesmisshandlung ist Gewalt gegen Kinder oder Jugendliche. Es handelt sich um eine besonders schwere Form der Verletzung des Kindeswohls. Unter dem Begriff Kindesmisshandlung werden physische als auch psychische Gewaltakte, sexueller Missbrauch …   Deutsch Wikipedia

  • APOBEC1 — Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1, also known as APOBEC1, is a human gene.cite web | title = Entrez Gene: APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1| url =… …   Wikipedia

  • Cymric (cat) — Cymric Alternative names Long haired Manx, Longhair Manx, Manx Longhair Origin Isle of Man …   Wikipedia

  • Abyssin — chocolat …   Wikipédia en Français

  • Abyssin (chat) — Abyssin Abyssin …   Wikipédia en Français

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”