Nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase

nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase
Identifiers
EC number	2.7.7.28
CAS number	37278-26-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase (EC 2.7.7.28) is an enzyme that catalyzes the chemical reaction

nucleoside triphosphate + alpha-D-aldose 1-phosphate $\rightleftharpoons$ diphosphate + NDP-hexose

Thus, the two substrates of this enzyme are nucleoside triphosphate and alpha-D-aldose 1-phosphate, whereas its two products are diphosphate and NDP-hexose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase. Other names in common use include NDP hexose pyrophosphorylase, hexose 1-phosphate nucleotidyltransferase, hexose nucleotidylating enzyme, nucleoside diphosphohexose pyrophosphorylase, hexose-1-phosphate guanylyltransferase, GTP:alpha-D-hexose-1-phosphate guanylyltransferase, GDP hexose pyrophosphorylase, guanosine diphosphohexose pyrophosphorylase, nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase, and NTP:hexose-1-phosphate nucleotidyltransferase.

References

• Verachtert H, Rodriguez P, Bass ST, Hansen RG (1966). "Purification and properties of guanosine diphosphate hexose pyrophosphorylase from mammalian tissues". J. Biol. Chem. 241 (9): 2007–13. PMID 5946626. 
• Hansen RG, Verachtert H, Rodriguez P and Bass ST (1966). "GDP-hexose pyrophosphorylase from liver". Methods Enzymol.. Methods in Enzymology 8: 269–271. doi:10.1016/0076-6879(66)08048-0. ISBN 9780121818081. 

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