- NADPH-hemoprotein reductase
In
enzymology , a NADPH---hemoprotein reductase (EC number|1.6.2.4) is anenzyme that catalyzes thechemical reaction :NADPH + H+ + n oxidized hemoprotein NADP+ + n reduced hemoprotein
The 3 substrates of this enzyme are NADPH, H+, and
oxidized hemoprotein , whereas its two products are NADP+ andreduced hemoprotein .This enzyme belongs to the family of
oxidoreductase s, specifically those acting on NADH or NADPH with a heme protein as acceptor. The systematic name of this enzyme class is NADPH:hemoprotein oxidoreductase. Other names in common use include CPR, FAD-cytochrome c reductase, NADP---cytochrome c reductase, NADP---cytochrome reductase, NADPH-dependent cytochrome c reductase, NADPH:P-450 reductase, NADPH:ferrihemoprotein oxidoreductase, NADPH---cytochrome P-450 oxidoreductase, NADPH---cytochrome c oxidoreductase, NADPH---cytochrome c reductase, NADPH---cytochrome p-450 reductase, NADPH---ferricytochrome c oxidoreductase, NADPH---ferrihemoprotein reductase, TPNH2 cytochrome c reductase, TPNH-cytochrome c reductase, aldehyde reductase (NADPH-dependent), cytochrome P-450 reductase, cytochrome c reductase (reduced nicotinamide adenine dinucleotide, phosphate, NADPH, NADPH-dependent), dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c, reductase, ferrihemoprotein P-450 reductase, reduced nicotinamide adenine dinucleotide phosphate-cytochrome c, reductase, reductase, cytochrome c (reduced nicotinamide adenine dinucleotide, and phosphate). It has 2 cofactors:FAD , andFMN .tructural studies
As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1AMO, PDB link|1B1C, PDB link|1J9Z, PDB link|1JA0, PDB link|1JA1, PDB link|1YQO, PDB link|1YQP, PDB link|2BF4, PDB link|2BN4, and PDB link|2BPO.
References
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*External links
::"The
CAS registry number for this enzyme class is CAS registry|9023-03-4."Gene Ontology (GO) codes
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