Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)

In enzymology, a glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (EC number|1.2.1.12) is an enzyme that catalyzes the chemical reaction

:D-glyceraldehyde 3-phosphate + phosphate + NAD⁺ $ightleftharpoons$ 3-phospho-D-glyceroyl phosphate + NADH + H⁺

The 3 substrates of this enzyme are D-glyceraldehyde 3-phosphate, phosphate, and NAD⁺, whereas its 3 products are 3-phospho-D-glyceroyl phosphate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating). Other names in common use include triosephosphate dehydrogenase, dehydrogenase, glyceraldehyde phosphate, phosphoglyceraldehyde dehydrogenase, 3-phosphoglyceraldehyde dehydrogenase, NAD+-dependent glyceraldehyde phosphate dehydrogenase, glyceraldehyde phosphate dehydrogenase (NAD+), glyceraldehyde-3-phosphate dehydrogenase (NAD+), NADH-glyceraldehyde phosphate dehydrogenase, and glyceraldehyde-3-P-dehydrogenase. This enzyme participates in glycolysis / gluconeogenesis.

tructural studies

As of late 2007, 49 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1A7K, PDB link|1B7G, PDB link|1CER, PDB link|1CF2, PDB link|1CRW, PDB link|1DBV, PDB link|1DC3, PDB link|1DC4, PDB link|1DC5, PDB link|1DC6, PDB link|1DSS, PDB link|1GAD, PDB link|1GAE, PDB link|1GD1, PDB link|1GGA, PDB link|1GPD, PDB link|1GYP, PDB link|1GYQ, PDB link|1HDG, PDB link|1I32, PDB link|1I33, PDB link|1IHX, PDB link|1IHY, PDB link|1J0X, PDB link|1K3T, PDB link|1ML3, PDB link|1NPT, PDB link|1NQ5, PDB link|1NQA, PDB link|1NQO, PDB link|1OBF, PDB link|1QXS, PDB link|1S7C, PDB link|1SZJ, PDB link|1U8F, PDB link|1VC2, PDB link|1YWG, PDB link|1ZNQ, PDB link|2B4R, PDB link|2B4T, PDB link|2DBV, PDB link|2EP7, PDB link|2G82, PDB link|2GD1, PDB link|2I5P, PDB link|3DBV, PDB link|3GPD, PDB link|4DBV, and PDB link|4GPD.

References

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* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 243-273.
* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 243-273.
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External links

::"The CAS registry number for this enzyme class is CAS registry|9001-50-7."

Gene Ontology (GO) codes