Glyoxylate reductase (NADP+)

Glyoxylate reductase (NADP+)

In enzymology, a glyoxylate reductase (NADP+) (EC number|1.1.1.79) is an enzyme that catalyzes the chemical reaction

:glycolate + NADP+ ightleftharpoons glyoxylate + NADPH + H+

Thus, the two substrates of this enzyme are glycolate and NADP+, whereas its 3 products are glyoxylate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycolate:NADP+ oxidoreductase. Other names in common use include NADPH-glyoxylate reductase, and glyoxylate reductase (NADP+). This enzyme participates in pyruvate metabolism and glyoxylate and dicarboxylate metabolism.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2GCG, PDB link|2H1S, and PDB link|2Q50.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37250-17-2."

Gene Ontology (GO) codes


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