2-hydroxy-3-oxopropionate reductase

2-hydroxy-3-oxopropionate reductase

In enzymology, a 2-hydroxy-3-oxopropionate reductase (EC number|1.1.1.60) is an enzyme that catalyzes the chemical reaction

:(R)-glycerate + NAD(P)+ ightleftharpoons 2-hydroxy-3-oxopropanoate + NAD(P)H + H+

The 3 substrates of this enzyme are (R)-glycerate, NAD+, and NADP+, whereas its 4 products are 2-hydroxy-3-oxopropanoate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-glycerate:NAD(P)+ oxidoreductase. This enzyme is also called tartronate semialdehyde reductase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|1YB4.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9028-68-6."

Gene Ontology (GO) codes


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  • List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH …   Wikipedia

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