NK012

NK012 is a 'nanodevice' formulation of SN-38 (an irinotecan metabolite). NK012 is an SN-38-releasing nanodevice constructed by covalently attaching SN-38 to the block copolymer PEG-PGlu, followed by self-assembly of amphiphilic block copolymers in aqueous media.^{[1] [2]}

It has entered phase II clinical trials for triple-negative breast cancer and relapsed small cell lung cancer^[3].

References

1. ^ http://www.cancer.gov/drugdictionary/?CdrID=574615
2. ^ Sumitomo et al. (2008). "Novel SN-38–Incorporated Polymeric Micelle, NK012, Strongly Suppresses Renal Cancer Progression". http://cancerres.aacrjournals.org/content/68/6/1631.abstract. 
3. ^ http://clinicaltrials.gov/ct2/results?term=NK012

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