5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole

5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole

5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole, referred to as DRB, is a chemical compound that inhibits transcription elongation by RNA Polymerase II. Sensitivity to DRB is dependent on DSIF, NELF, and P-TEFb. DRB is a nucleoside analog and also inhibits some protein kinases.cite journal | author = Yamaguchi, Y. | coauthors = Takagi, T.; Wada, T.; Yano, K.; Furuya, A.; Sugimoto, S.; Hasegawa, J.; Handa, H. | title = NELF, a Multisubunit Complex Containing RD, Cooperates with DSIF to Repress RNA Polymerase II Elongation. | journal = Cell | volume = 97 | pages =41-51 | year = 1999 | pmid= 10199401]

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  • DRB (disambiguation) — DRB may refer to: *Defence Research and Development Canada (the Canadian Defence Research Board) *Distributed Ruby *DRB HICOM, a Malaysian automotive company *DRB Sports Cars, an Australian sports car company *5,6 dichloro 1 beta D… …   Wikipedia

  • DRB — may refer to: Defence Research and Development Canada, the Canadian Defence Research Board Deutsche Reichsbahn, the German Imperial Railways or its wartime locomotive classes such as the DRB Class 50 Deutscher Richterbund, the German Association… …   Wikipedia

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