Selamectin

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CASNo=165108-07-6
PubChem=9578507
SMILES=CC1CCC2(CC3CC(O2)CC= C(C(C(C=CC=C4COC5C4(C(C= C(C5=NO)C)C(=O)O3)O)C) OC6CC(C(C(O6)C)O) OC)C)OC1C7CCCCC7
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Formula=C₄₃H₆₃NO₁₁
MolarMass=769.96 g/mol
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Selamectin is the active ingredient in the prescription drug Revolution (manufactured by Pfizer Canada . [ cite web|url=http://pfizercanen.naccvp.com/view_label.php?prodnum=1198329 |title=Label for Revolution (selamectin topical solution) Topical Parasiticide for Dogs and Cats |accessdate=2008-07-05 |publisher=Pfizer Canada Inc. ] ), a topical insecticide and antihelminthic used on dogs and cats. It controls outbreaks of fleas, heartworm, hookworms, roundworms, and ear mites. Selamectin is not approved for human use.

How it works

Selamectin disables parasites by replacing glutamate in their muscle synapses; glutamate is the amino acid which normally interacts with the receptors that open chloride channels into the muscle. Selamectin interferes with this process; it activates the chloride current without desensitization, allowing chloride ions to enter the nerve cells and causing neuromuscular paralysis, impaired muscular contraction, and eventual death.

Selamectin fights both internal and surface parasitic infection. Absorbed into the body through the skin and hair follicles, it travels through the bloodstream, intestines, and sebaceous glands; parasites ingest the drug when they feed on the animal's blood.

A 2003 report by E. Pipano in the Israel Journal of Veterinary Medicine describes the testing of Selamectin for safety and effectiveness, and the positive results [ cite journal|title=RECENT DEVELOPMENTS IN THE CONTROL OF ECTOPARASITES AND ENDOPARASITES OF DOGS AND CATS WITH SELAMECTIN|journal=Israel Journal of Veterianry Medicine|date=2003|first=E.|last=Pipano|coauthors=|volume=58|issue=2-3|pages=|id= |url=http://www.isrvma.org/article/58_2_1.htm|format=|accessdate=2008-07-05 ] .

References

External links

* [http://www.pfizer.ca Pfizer Canada]