Cafestol

drugbox
width = 300

!240px
CAS_number = 469-83-0
IUPAC_name = ("3bS,5aS,7R,8R,10aS,10bS")-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro-
7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta [5,6] naphtho [2,1-b] furan-7-methanol
C=20 | H=28 | O=3
PubChem = 108052
molecular_weight = 316.439 g/mol
melting_point = 158
melting_high = 162
synonyms =
metabolism =
excretion =
legal_status = Legal everywhere
routes_of_administration =

Cafestol is a diterpene molecule present in coffee.

A typical bean of "Coffea arabica" contains about 0.6% cafestol by weight. Cafestol is present in highest quantity in unfiltered coffee drinks such as French press coffee or Turkish coffee. In filtered coffee drinks such as drip brewed coffee, it is present in only negligible amounts.

Studies have shown that regular consumption of boiled coffee increases serum cholesterol by 8% in men and 10% in women. For those drinking filter coffee, the effect was only significant for women.

Cafestol has also shown anticarcinogenic properties in rats.

According to a 2007 study from Dr. David Moore's lab at Baylor College of Medicine [http://www.ncbi.nlm.nih.gov/pubmed/17456796] , cafestol may act as an agonist ligand for the nuclear receptor Farnesoid X receptor and Pregnane X receptor, blocking cholesterol homeostasis.

ee also

* Kahweol

External links

* [http://ntp.niehs.nih.gov/ntp/htdocs/Chem_Background/ExSumPdf/Cafestol.pdf NIH review of toxicology of cafestol and kahweol]

* [http://mend.endojournals.org/cgi/content/full/21/7/1603 The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors]