- CAPN9
Calpain 9, also known as CAPN9, is a human
gene .cite web | title = Entrez Gene: CAPN9 calpain 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10753| accessdate = ]PBB_Summary
section_title =
summary_text = Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: CAPN9 calpain 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10753| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Huang Y, Wang KK |title=The calpain family and human disease. |journal=Trends in molecular medicine |volume=7 |issue= 8 |pages= 355-62 |year= 2001 |pmid= 11516996 |doi=
*cite journal | author=Suzuki K, Sorimachi H, Yoshizawa T, "et al." |title=Calpain: novel family members, activation, and physiologic function. |journal=Biol. Chem. Hoppe-Seyler |volume=376 |issue= 9 |pages= 523-9 |year= 1996 |pmid= 8561910 |doi=
*cite journal | author=Davis TL, Walker JR, Finerty PJ, "et al." |title=The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. |journal=J. Mol. Biol. |volume=366 |issue= 1 |pages= 216-29 |year= 2007 |pmid= 17157313 |doi= 10.1016/j.jmb.2006.11.037
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yoshikawa Y, Mukai H, Hino F, "et al." |title=Isolation of two novel genes, down-regulated in gastric cancer. |journal=Jpn. J. Cancer Res. |volume=91 |issue= 5 |pages= 459-63 |year= 2000 |pmid= 10835488 |doi=
*cite journal | author=Lee HJ, Tomioka S, Kinbara K, "et al." |title=Characterization of a human digestive tract-specific calpain, nCL-4, expressed in the baculovirus system. |journal=Arch. Biochem. Biophys. |volume=362 |issue= 1 |pages= 22-31 |year= 1999 |pmid= 9917325 |doi= 10.1006/abbi.1998.1021
*cite journal | author=Lee HJ, Sorimachi H, Jeong SY, "et al." |title=Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract. |journal=Biol. Chem. |volume=379 |issue= 2 |pages= 175-83 |year= 1998 |pmid= 9524069 |doi=PBB_Controls
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