SH3RF1

SH3 domain containing ring finger 1, also known as SH3RF1, is a human gene.cite web | title = Entrez Gene: SH3RF1 SH3 domain containing ring finger 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57630| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.cite web | title = Entrez Gene: SH3RF1 SH3 domain containing ring finger 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57630| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lyons TR, Thorburn J, Ryan PW, "et al." |title=Regulation of the Pro-apoptotic scaffolding protein POSH by Akt. |journal=J. Biol. Chem. |volume=282 |issue= 30 |pages= 21987-97 |year= 2007 |pmid= 17535800 |doi= 10.1074/jbc.M704321200
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Alroy I, Tuvia S, Greener T, "et al." |title=The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 5 |pages= 1478-83 |year= 2005 |pmid= 15659549 |doi= 10.1073/pnas.0408717102
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Figueroa C, Tarras S, Taylor J, Vojtek AB |title=Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex. |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 47922-7 |year= 2004 |pmid= 14504284 |doi= 10.1074/jbc.M307357200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902
*cite journal | author=Nagase T, Kikuno R, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143-50 |year= 2000 |pmid= 10819331 |doi=
*cite journal | author=Tapon N, Nagata K, Lamarche N, Hall A |title=A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways. |journal=EMBO J. |volume=17 |issue= 5 |pages= 1395-404 |year= 1998 |pmid= 9482736 |doi= 10.1093/emboj/17.5.1395

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