MRPL23

Mitochondrial ribosomal protein L23, also known as MRPL23, is a human gene.cite web | title = Entrez Gene: MRPL23 mitochondrial ribosomal protein L23| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6150| accessdate = ]

PBB_Summary
section_title =
summary_text = Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11.cite web | title = Entrez Gene: MRPL23 mitochondrial ribosomal protein L23| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6150| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sun XX, Dai MS, Lu H |title=5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction. |journal=J. Biol. Chem. |volume=282 |issue= 11 |pages= 8052-9 |year= 2007 |pmid= 17242401 |doi= 10.1074/jbc.M610621200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Zhang Z, Gerstein M |title=Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. |journal=Genomics |volume=81 |issue= 5 |pages= 468-80 |year= 2003 |pmid= 12706105 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=O'Brien TW |title=Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease. |journal=Gene |volume=286 |issue= 1 |pages= 73-9 |year= 2002 |pmid= 11943462 |doi=
*cite journal | author=Kenmochi N, Suzuki T, Uechi T, "et al." |title=The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. |journal=Genomics |volume=77 |issue= 1-2 |pages= 65-70 |year= 2001 |pmid= 11543634 |doi= 10.1006/geno.2001.6622
*cite journal | author=Suzuki T, Terasaki M, Takemoto-Hori C, "et al." |title=Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21724-36 |year= 2001 |pmid= 11279069 |doi= 10.1074/jbc.M100432200
*cite journal | author=Tsang P, Gilles F, Yuan L, "et al." |title=A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues. |journal=Hum. Mol. Genet. |volume=4 |issue= 9 |pages= 1499-507 |year= 1996 |pmid= 8541832 |doi=

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