- CROT (gene)
Carnitine O-octanoyltransferase, also known as CROT, is a human
gene .cite web | title = Entrez Gene: CROT carnitine O-octanoyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54677| accessdate = ]PBB_Summary
section_title =
summary_text = Carnitine octanoyltransferase (EC 2.3.1.137) is a carnitine acyltransferase that catalyzes the reversible transfer of fatty acyl groups between CoA and carnitine. This provides a crucial step in the transport of medium- and long-chain acyl-CoA out of the mammalian peroxisome to the cytosol and mitochondria. See also CRAT (MIM 600184). Van der Leij et al. (2000) reviewed the function, structural features, and phylogenetics of human carnitine acyltransferase genes, including CROT. [supplied by OMIM] cite web | title = Entrez Gene: CROT carnitine O-octanoyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54677| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=van der Leij FR, Huijkman NC, Boomsma C, "et al." |title=Genomics of the human carnitine acyltransferase genes. |journal=Mol. Genet. Metab. |volume=71 |issue= 1-2 |pages= 139-53 |year= 2000 |pmid= 11001805 |doi= 10.1006/mgme.2000.3055
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Morillas M, Gómez-Puertas P, Rubí B, "et al." |title=Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain. |journal=J. Biol. Chem. |volume=277 |issue= 13 |pages= 11473-80 |year= 2002 |pmid= 11790793 |doi= 10.1074/jbc.M111628200
*cite journal | author=Ferdinandusse S, Mulders J, IJlst L, "et al." |title=Molecular cloning and expression of human carnitine octanoyltransferase: evidence for its role in the peroxisomal beta-oxidation of branched-chain fatty acids. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 1 |pages= 213-8 |year= 1999 |pmid= 10486279 |doi= 10.1006/bbrc.1999.1340
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138PBB_Controls
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