AUP1

Ancient ubiquitous protein 1, also known as AUP1, is a human gene.cite web | title = Entrez Gene: AUP1 ancient ubiquitous protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=550| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.cite web | title = Entrez Gene: AUP1 ancient ubiquitous protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=550| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Karpisheva KV, Tauber B, Kisliakova TV, Dobner T |title= [A new human cellular protein AUP1. III. The intracellular localization of AUP1 protein in different human and rat cell lines] |journal=Tsitologiia |volume=44 |issue= 9 |pages= 846-51 |year= 2003 |pmid= 12534238 |doi=
*cite journal | author=Karpisheva KV, Touber B, Kisliakova TV, Dobner T |title= [A new human cellular protein AUP1. II. cDNA cloning, genomic organization of Aup1 gene ans preliminary characterization of human AUP1 protein] |journal=Tsitologiia |volume=44 |issue= 9 |pages= 839-45 |year= 2003 |pmid= 12534237 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kato A, Kawamata N, Tamayose K, "et al." |title=Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28934-41 |year= 2002 |pmid= 12042322 |doi= 10.1074/jbc.M204340200
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi=
*cite journal | author=Jang W, Weber JS, Bashir R, "et al." |title=Aup1, a novel gene on mouse chromosome 6 and human chromosome 2p13. |journal=Genomics |volume=36 |issue= 2 |pages= 366-8 |year= 1997 |pmid= 8812468 |doi= 10.1006/geno.1996.0477

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