GNB1L

Guanine nucleotide binding protein (G protein), beta polypeptide 1-like, also known as GNB1L, is a human gene.cite web | title = Entrez Gene: GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54584| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 6 WD repeats and is highly expressed in the heart. The gene maps to the region on chromosome 22q11, which is deleted in DiGeorge syndrome, trisomic in derivative 22 syndrome and tetrasomic in cat-eye syndrome. Therefore, this gene may contribute to the etiology of those disorders. Transcripts from this gene share exons with some transcripts from the C22orf29 gene.cite web | title = Entrez Gene: GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54584| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Williams NM, Glaser B, Norton N, "et al." |title=Strong evidence that GNB1L is associated with schizophrenia. |journal=Hum. Mol. Genet. |volume=17 |issue= 4 |pages= 555-66 |year= 2008 |pmid= 18003636 |doi= 10.1093/hmg/ddm330
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84
*cite journal | author=Sarbassov DD, Ali SM, Kim DH, "et al." |title=Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. |journal=Curr. Biol. |volume=14 |issue= 14 |pages= 1296-302 |year= 2004 |pmid= 15268862 |doi= 10.1016/j.cub.2004.06.054
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Funke B, Pandita RK, Morrow BE |title=Isolation and characterization of a novel gene containing WD40 repeats from the region deleted in velo-cardio-facial/DiGeorge syndrome on chromosome 22q11. |journal=Genomics |volume=73 |issue= 3 |pages= 264-71 |year= 2001 |pmid= 11350118 |doi= 10.1006/geno.2000.6506
*cite journal | author=Hirosawa M, Nagase T, Murahashi Y, "et al." |title=Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. |journal=DNA Res. |volume=8 |issue= 1 |pages= 1-9 |year= 2001 |pmid= 11258795 |doi=
*cite journal | author=Gong L, Liu M, Jen J, Yeh ET |title=GNB1L, a gene deleted in the critical region for DiGeorge syndrome on 22q11, encodes a G-protein beta-subunit-like polypeptide. |journal=Biochim. Biophys. Acta |volume=1494 |issue= 1-2 |pages= 185-8 |year= 2000 |pmid= 11072084 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031

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