FGF21

Fibroblast growth factor 21, also known as FGF21, is a human gene.cite journal | author = Nishimura T, Nakatake Y, Konishi M, Itoh N | title = Identification of a novel FGF, FGF-21, preferentially expressed in the liver | journal = Biochim. Biophys. Acta | volume = 1492 | issue = 1 | pages = 203–6 | year = 2000 | month = June | pmid = 10858549 | doi = 10.1016/S0167-4781(00)00067-1 | url = | issn = ] cite web | title = Entrez Gene: FGF21 fibroblast growth factor 21| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26291| accessdate = ] The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.

Function

FGF21 stimulates glucose uptake in adipocytes but not in other cell types.cite journal | author = Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, Sandusky GE, Hammond LJ, Moyers JS, Owens RA, Gromada J, Brozinick JT, Hawkins ED, Wroblewski VJ, Li DS, Mehrbod F, Jaskunas SR, Shanafelt AB | title = FGF-21 as a novel metabolic regulator | journal = J. Clin. Invest. | volume = 115 | issue = 6 | pages = 1627–35 | year = 2005 | month = June | pmid = 15902306 | pmc = 1088017 | doi = 10.1172/JCI23606 | url = | issn = ] This effect is additive to the activity of insulin. FGF21 treatment of adipocytes is associated with phosphorylation of FRS2, a protein linking FGF receptors to the Ras/MAP kinase pathway. FGF21 injection in ob/ob mice results in an increase in Glut1 in adipose tissue. FGF21 also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents. Treatment of animals with FGF21 results in increased energy expenditure, fat utilization and lipid excretion.cite journal | author = Coskun T, Bina HA, Schneider MA, Dunbar JD, Hu CC, Chen Y, Moller DE, Kharitonenkov A | title = FGF21 Corrects Obesity in Mice | journal = Endocrinology | volume = | issue = | pages = | year = 2008 | month = August | pmid = 18687777 | doi = 10.1210/en.2008-0816 | url = | issn = ]

Beta Klotho (gene|KLB) functions as a cofactor essential for FGF21 activity.cite journal | author = Ogawa Y, Kurosu H, Yamamoto M, Nandi A, Rosenblatt KP, Goetz R, Eliseenkova AV, Mohammadi M, Kuro-o M | title = BetaKlotho is required for metabolic activity of fibroblast growth factor 21 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 104 | issue = 18 | pages = 7432–7 | year = 2007 | month = May | pmid = 17452648 | pmc = 1855074 | doi = 10.1073/pnas.0701600104 | url = | issn = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chen WW, Li L, Yang GY, "et al." |title=Circulating FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitus. |journal=Exp. Clin. Endocrinol. Diabetes |volume=116 |issue= 1 |pages= 65–8 |year= 2008 |pmid= 17926232 |doi= 10.1055/s-2007-985148
*cite journal | author=Ogawa Y, Kurosu H, Yamamoto M, "et al." |title=BetaKlotho is required for metabolic activity of fibroblast growth factor 21. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 18 |pages= 7432–7 |year= 2007 |pmid= 17452648 |doi= 10.1073/pnas.0701600104
*cite journal | author=Kharitonenkov A, Wroblewski VJ, Koester A, "et al." |title=The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. |journal=Endocrinology |volume=148 |issue= 2 |pages= 774–81 |year= 2007 |pmid= 17068132 |doi= 10.1210/en.2006-1168
*cite journal | author=Kharitonenkov A, Shiyanova TL, Koester A, "et al." |title=FGF-21 as a novel metabolic regulator. |journal=J. Clin. Invest. |volume=115 |issue= 6 |pages= 1627–35 |year= 2005 |pmid= 15902306 |doi= 10.1172/JCI23606
*cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504
*cite journal | author=Popovici C, Conchonaud F, Birnbaum D, Roubin R |title=Functional phylogeny relates LET-756 to fibroblast growth factor 9. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40146–52 |year= 2004 |pmid= 15199049 |doi= 10.1074/jbc.M405795200
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Nishimura T, Nakatake Y, Konishi M, Itoh N |title=Identification of a novel FGF, FGF-21, preferentially expressed in the liver. |journal=Biochim. Biophys. Acta |volume=1492 |issue= 1 |pages= 203–6 |year= 2000 |pmid= 10858549 |doi=

External Links

*
*
*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes