WWC1

WW and C2 domain containing 1, also known as WWC1, is a human gene.cite web | title = Entrez Gene: WWC1 WW and C2 domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23286| accessdate = ] PBB_Summary
section_title =
summary_text = A polymorphism in the gene (rs17070145) has been association with human memory performance in one 2006 study.cite journal
author = Papassotiropoulos A, Stephan DA, Huentelman MJ, Hoerndli FJ, Craig DW, Pearson JV, Huynh KD, Brunner F, Corneveaux J, Osborne D, Wollmer MA, Aerni A, Coluccia D, Hänggi J, Mondadori CR, Buchmann A, Reiman EM, Caselli RJ, Henke K, de Quervain DJ
title = Common Kibra alleles are associated with human memory performance
journal = Science (journal)
volume = 314
issue = 5798
pages = 475–8
year = 2006
month = October
pmid = 17053149
doi = 10.1126/science.1129837] It was replicated in a study with elderly,cite journal
author = Schaper K, Kolsch H, Popp J, Wagner M, Jessen F
title = KIBRA gene variants are associated with episodic memory in healthy elderly
journal = Neurobiol. Aging
volume = 29
issue = 7
pages = 1123–5
year = 2008
month = July
pmid = 17353070
doi = 10.1016/j.neurobiolaging.2007.02.001] but failed to in a large study with 584 subjects.cite journal
author = Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KN, Wagoner AP, Gumbs CE, Giegling I, Möller HJ, Francks C, Muglia P, Roses A, Gibson G, Weale ME, Rujescu D, Goldstein DB
title = Failure to replicate effect of Kibra on human memory in two large cohorts of European origin
journal = Am. J. Med. Genet. B Neuropsychiatr. Genet.
volume = 147B
issue = 5
pages = 667–8
year = 2008
month = July
pmid = 18205171
doi = 10.1002/ajmg.b.30658] A newer study has also investigated the link to Alzheimer's disease. [Cite news
work = ScienceDaily
title = Brain Protein Linked To Alzheimer's Disease
url = http://www.sciencedaily.com/releases/2008/09/080915132658.htm
date = 2008-09-15
accessdate = 2008-09-16] cite journal
author = Corneveaux JJ, Liang WS, Reiman EM, Webster JA, Myers AJ, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Craig DW, Coon KD, Dunckley T, Bandy D, Lee W, Chen K, Beach TG, Mastroeni D, Grover A, Ravid R, Sando SB, Aasly JO, Heun R, Jessen F, Kölsch H, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Papassotiropoulos A, Stephan DA, Huentelman MJ
title = Evidence for an association between KIBRA and late-onset Alzheimer's disease
journal = Neurobiol. Aging
volume =
issue =
pages =
year = 2008
month = September
pmid = 18789830
doi = 10.1016/j.neurobiolaging.2008.07.014]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Need AC, Attix DK, McEvoy JM, "et al." |title=Failure to replicate effect of kibra on human memory in two large cohorts of European origin. |journal= |volume= |issue= |pages= |year= |pmid= 18205171 |doi= 10.1002/ajmg.b.30658
*cite journal | author=Almeida OP, Schwab SG, Lautenschlager NT, "et al." |title=KIBRA Genetic Polymorphism Influences Episodic Memory in Later Life, but Does Not Increase the Risk of Mild Cognitive Impairment. |journal= |volume= |issue= |pages= |year= |pmid= 18194457 |doi= 10.1111/j.1582-4934.2008.00229.x
*cite journal | author=Hilton HN, Stanford PM, Harris J, "et al." |title=KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. |journal=Biochim. Biophys. Acta |volume=1783 |issue= 3 |pages= 383–93 |year= 2008 |pmid= 18190796 |doi= 10.1016/j.bbamcr.2007.12.007
*cite journal | author=Rodríguez-Rodríguez E, Infante J, Llorca J, "et al." |title=Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk. |journal=Neurobiol. Aging |volume= |issue= |pages= |year= |pmid= 17707552 |doi= 10.1016/j.neurobiolaging.2007.07.003
*cite journal | author=Schaper K, Kolsch H, Popp J, "et al." |title=KIBRA gene variants are associated with episodic memory in healthy elderly. |journal=Neurobiol. Aging |volume= |issue= |pages= |year= |pmid= 17353070 |doi= 10.1016/j.neurobiolaging.2007.02.001
*cite journal | author=Papassotiropoulos A, Stephan DA, Huentelman MJ, "et al." |title=Common Kibra alleles are associated with human memory performance. |journal=Science |volume=314 |issue= 5798 |pages= 475–8 |year= 2006 |pmid= 17053149 |doi= 10.1126/science.1129837
*cite journal | author=Rayala SK, den Hollander P, Manavathi B, "et al." |title=Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells. |journal=J. Biol. Chem. |volume=281 |issue= 28 |pages= 19092–9 |year= 2006 |pmid= 16684779 |doi= 10.1074/jbc.M600021200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Büther K, Plaas C, Barnekow A, Kremerskothen J |title=KIBRA is a novel substrate for protein kinase Czeta. |journal=Biochem. Biophys. Res. Commun. |volume=317 |issue= 3 |pages= 703–7 |year= 2004 |pmid= 15081397 |doi= 10.1016/j.bbrc.2004.03.107
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Kremerskothen J, Plaas C, Büther K, "et al." |title=Characterization of KIBRA, a novel WW domain-containing protein. |journal=Biochem. Biophys. Res. Commun. |volume=300 |issue= 4 |pages= 862–7 |year= 2003 |pmid= 12559952 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355–64 |year= 1999 |pmid= 10048485 |doi=

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