COX6C

Cytochrome c oxidase subunit VIc, also known as COX6C, is a human gene.cite web | title = Entrez Gene: COX6C cytochrome c oxidase subunit VIc| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1345| accessdate = ]

PBB_Summary
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summary_text = Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse COX subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene COX6CP1 has been found on chromosomes 16p12.cite web | title = Entrez Gene: COX6C cytochrome c oxidase subunit VIc| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1345| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lenka N, Vijayasarathy C, Mullick J, Avadhani NG |title=Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=61 |issue= |pages= 309–44 |year= 1998 |pmid= 9752724 |doi=
*cite journal | author=Sirchia R, Luparello C |title=Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells. |journal=Biol. Chem. |volume=388 |issue= 5 |pages= 457–65 |year= 2007 |pmid= 17516841 |doi= 10.1515/BC.2007.059
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hofmann S, Lichtner P, Schuffenhauer S, "et al." |title=Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 3-4 |pages= 226–7 |year= 1999 |pmid= 10072584 |doi=
*cite journal | author=Kish SJ, Mastrogiacomo F, Guttman M, "et al." |title=Decreased brain protein levels of cytochrome oxidase subunits in Alzheimer's disease and in hereditary spinocerebellar ataxia disorders: a nonspecific change? |journal=J. Neurochem. |volume=72 |issue= 2 |pages= 700–7 |year= 1999 |pmid= 9930743 |doi=
*cite journal | author=Wang FL, Wang Y, Wong WK, "et al." |title=Two differentially expressed genes in normal human prostate tissue and in carcinoma. |journal=Cancer Res. |volume=56 |issue= 16 |pages= 3634–7 |year= 1996 |pmid= 8705997 |doi=
*cite journal | author=Otsuka M, Mizuno Y, Yoshida M, "et al." |title=Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc. |journal=Nucleic Acids Res. |volume=16 |issue= 22 |pages= 10916 |year= 1989 |pmid= 2849755 |doi=

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