Free fraction

Free fraction

The free fraction is a parameter in pharmacokinetics and receptor-ligand kinetics.One speaks of two different free fractions:
* "Plasma free fraction", previously referred to as ƒ1,Cite journal
title = Positron Emission Tomography Compartmental Models: A Basis Pursuit Strategy for Kinetic Modeling
author = Roger N. Gunn, Steve R. Gunn, Federico E. Turkheimer, John A. D. Aston and Vincent J. Cunningham
journal = J. Cereb. Blood Metab.
volume = 22
issue = 4
pages = 1425–1439
year = 2002
doi = 10.1097/00004647-200212000-00003 [http://www.nature.com/jcbfm/journal/v22/n12/fig_tab/9591337t4.html Table] ] is now referred to as ƒP according to consensus nomenclature. [Cite journal
author = Innis et al
title = Consensus nomenclature for in vivo imaging of reversibly binding radioligands
journal = J. Cereb Blood Flow and Metab.
year = 2007
volume = 27
issue = 9
pages = 1533–1539
doi = 10.1038/sj.jcbfm.9600493]
* "Tissue free fraction" (ƒND), previously referred to as ƒ2

The "plasma free fraction" is the fraction of the ligand at equilibrium in blood plasma that is not bound to plasma proteins.

See also

* Binding potential

References

Others

* Cite journal
author=Milak MS, Severance AJ, Ogden RT, Prabhakaran J, Kumar JS, Majo VJ, Mann JJ, Parsey RV
title=Modeling Considerations for 11C-CUMI-101, an Agonist Radiotracer for Imaging Serotonin 1A Receptor In Vivo with PET
journal=J. Nucl. Med.
volume = 49
issue = 4
pages = 587–596
year = 2008
pmid = 18344443
doi = 10.2967/jnumed.107.046540
url = http://jnm.snmjournals.org/cgi/pmidlookup?view=long&pmid=18344443


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