SAM-IV riboswitch

SAM-IV riboswitches are a kind of riboswitch that specifically binds S-adenosylmethionine (SAM) [cite journal |author=Weinberg Z, Regulski EE, Hammond MC, "et al" |title=The aptamer core of SAM-IV riboswitches mimics the ligand-binding site of SAM-I riboswitches |journal=RNA |volume= |issue= |pages= |year=2008 |pmid=18369181 |doi=10.1261/rna.988608] , a cofactor used in many methylation reactions. Originally identified by bioinformatics [cite journal |author=Weinberg Z, Barrick JE, Yao Z, "et al" |title=Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline |journal=Nucleic Acids Res. |volume=35 |issue=14 |pages=4809–19 |year=2007 |pmid=17621584 |doi=10.1093/nar/gkm487] , SAM-IV riboswitches are largely confined to the Actinomycetales, an order of Bacteria. Conserved features of SAM-IV riboswitch and experiments imply that they probably share a similar SAM-binding site to another class of SAM-binding riboswitches called SAM-I riboswitches. However, the scaffolds of these two types of riboswitch appear to be quite distinct.

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