- STAT5B
Signal transducer and activator of transcription 5B, also known as STAT5B, is a human
gene .PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the STAT family oftranscription factor s. In response tocytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset ofacute promyelocytic leukemia s (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [cite web | title = Entrez Gene: STAT5B signal transducer and activator of transcription 5B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6777| accessdate = ]ee also
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STAT5 References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW |title=Signaling through the JAK/STAT pathway, recent advances and future challenges. |journal=Gene |volume=285 |issue= 1-2 |pages= 1–24 |year= 2002 |pmid= 12039028 |doi=PBB_Controls
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