RGS13

Regulator of G-protein signalling 13, also known as RGS13, is a human gene.cite web | title = Entrez Gene: RGS13 regulator of G-protein signalling 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6003| accessdate = ]

RGS 13 is a member of R4 subfamily of RGS (Regualtors of G Protein Signaling) proteins which have only short peptide sequences flanking the RGS domain. RGS 13 suppresses the immunoglobulin E- mediated allergic responses.cite journal | author = Bansal G, Xie Z, Rao S, Nocka KH, Druey KM | title = Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13 | journal = Nat. Immunol. | volume = 9 | issue = 1 | pages = 73–80 | year = 2008 | pmid = 18026105 | doi = 10.1038/ni1533 | issn = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.cite web | title = Entrez Gene: RGS13 regulator of G-protein signalling 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6003| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Han JI, Huang NN, Kim DU, Kehrl JH |title=RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization. |journal=J. Leukoc. Biol. |volume=79 |issue= 6 |pages= 1357–68 |year= 2006 |pmid= 16565322 |doi= 10.1189/jlb.1105693
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Islam TC, Asplund AC, Lindvall JM, "et al." |title=High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma. |journal=Leukemia |volume=17 |issue= 9 |pages= 1880–90 |year= 2003 |pmid= 12970790 |doi= 10.1038/sj.leu.2403057
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Johnson EN, Druey KM |title=Functional characterization of the G protein regulator RGS13. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16768–74 |year= 2002 |pmid= 11875076 |doi= 10.1074/jbc.M200751200
*cite journal | author=Sierra DA, Gilbert DJ, Householder D, "et al." |title=Evolution of the regulators of G-protein signaling multigene family in mouse and human. |journal=Genomics |volume=79 |issue= 2 |pages= 177–85 |year= 2002 |pmid= 11829488 |doi= 10.1006/geno.2002.6693
*cite journal | author=Druey KM, Blumer KJ, Kang VH, Kehrl JH |title=Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. |journal=Nature |volume=379 |issue= 6567 |pages= 742–6 |year= 1996 |pmid= 8602223 |doi= 10.1038/379742a0

References

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